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gcgra glucagon receptor a [ Danio rerio (zebrafish) ]

Gene ID: 562973, updated on 9-Sep-2025
Official Symbol
gcgraprovided by ZNC
Official Full Name
glucagon receptor aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050516-1
See related
Ensembl:ENSDARG00000104022 AllianceGenome:ZFIN:ZDB-GENE-050516-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Enables glucagon receptor activity and peptide hormone binding activity. Acts upstream of or within regulation of glucose metabolic process. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in brain; heart; liver; male organism; and muscle. Human ortholog(s) of this gene implicated in Mahvash Disease and type 2 diabetes mellitus. Orthologous to human GCGR (glucagon receptor). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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See gcgra in Genome Data Viewer
Location:
chromosome: 3
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 3 NC_133178.1 (50904819..51072663, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 3 NC_007114.7 (49757792..49925286, complement)

Chromosome 3 - NC_133178.1Genomic Context describing neighboring genes Neighboring gene zinc-binding protein A33 Neighboring gene uncharacterized LOC103910319 Neighboring gene mas-related G-protein coupled receptor member X1-like Neighboring gene uncharacterized LOC103910321 Neighboring gene uncharacterized LOC110439301

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Integrated Metabolomics and Lipidomics Analysis Reveal Remodeling of Lipid Metabolism and Amino Acid Metabolism in Glucagon Receptor-Deficient Zebrafish. Bai X, et al. Front Cell Dev Biol, 2020. PMID 33520988, Free PMC Article
  2. Evolution of new hormone function: loss and gain of a receptor. Irwin DM, et al. J Hered, 2005 May-Jun. PMID 15653559
  3. Expression of glucose-dependent insulinotropic polypeptide in the zebrafish. Musson MC, et al. Am J Physiol Regul Integr Comp Physiol, 2009 Dec. PMID 19793957, Free PMC Article
  4. Glucagon receptor inactivation leads to α-cell hyperplasia in zebrafish. Li M, et al. J Endocrinol, 2015 Nov. PMID 26446275, Free PMC Article
  5. Hyperaminoacidemia from interrupted glucagon signaling increases pancreatic acinar cell proliferation and size via mTORC1 and YAP pathways. Dai C, et al. iScience, 2024 Dec 20. PMID 39720531, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables gastric inhibitory peptide receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables glucagon receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucagon receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide hormone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of glucose metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
glucagon receptor
Names
GLUCR
gcgr
zfGR
zgcg-r2
zmp:0000000731

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133178.1 Reference GRCz12tu Primary Assembly

    Range
    50904819..51072663 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017354821.4 → XP_017210310.1  glucagon receptor isoform X2

    UniProtKB/TrEMBL
    A0A8M6YWT8
    Conserved Domains (3) summary
    pfam02793
    Location:51 → 113
    HRM; Hormone receptor domain
    cd14964
    Location:127 → 151
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:124 → 402
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_009299727.5 → XP_009298002.1  glucagon receptor isoform X1

    See identical proteins and their annotated locations for XP_009298002.1

    UniProtKB/TrEMBL
    A0A8M3B187, E7FB43
    Conserved Domains (3) summary
    pfam02793
    Location:51 → 113
    HRM; Hormone receptor domain
    cd14964
    Location:127 → 151
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:124 → 410
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. XM_073944994.1 → XP_073801095.1  glucagon receptor isoform X2

    UniProtKB/TrEMBL
    A0A8M6YWT8

  4. XM_073944987.1 → XP_073801088.1  glucagon receptor isoform X1

    UniProtKB/TrEMBL
    A0A8M3B187, E7FB43

  5. XM_073944995.1 → XP_073801096.1  glucagon receptor isoform X2

    UniProtKB/TrEMBL
    A0A8M6YWT8

  6. XM_068218119.2 → XP_068074220.1  glucagon receptor isoform X1

    UniProtKB/TrEMBL
    A0A8M3B187, E7FB43

  7. XM_073944993.1 → XP_073801094.1  glucagon receptor isoform X2

    UniProtKB/TrEMBL
    A0A8M6YWT8

  8. XM_068218118.2 → XP_068074219.1  glucagon receptor isoform X1

    UniProtKB/TrEMBL
    A0A8M3B187, E7FB43

  9. XM_073944996.1 → XP_073801097.1  glucagon receptor isoform X2

    UniProtKB/TrEMBL
    A0A8M6YWT8

  10. XM_073944990.1 → XP_073801091.1  glucagon receptor isoform X1

    UniProtKB/TrEMBL
    A0A8M3B187, E7FB43

  11. XM_073944989.1 → XP_073801090.1  glucagon receptor isoform X1

    UniProtKB/TrEMBL
    A0A8M3B187, E7FB43

  12. XM_073944998.1 → XP_073801099.1  glucagon receptor isoform X2

    UniProtKB/TrEMBL
    A0A8M6YWT8

  13. XM_073944991.1 → XP_073801092.1  glucagon receptor isoform X1

    UniProtKB/TrEMBL
    A0A8M3B187, E7FB43

  14. XM_073944997.1 → XP_073801098.1  glucagon receptor isoform X2

    UniProtKB/TrEMBL
    A0A8M6YWT8

  15. XM_686342.9 → XP_691434.5  glucagon receptor isoform X1

    See identical proteins and their annotated locations for XP_691434.5

    UniProtKB/TrEMBL
    A0A8M3B187, E7FB43
    Conserved Domains (3) summary
    pfam02793
    Location:51 → 113
    HRM; Hormone receptor domain
    cd14964
    Location:127 → 151
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:124 → 410
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version

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