helq helicase, POLQ like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: helqprovided by ZNC
Official Full Name: helicase, POLQ likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060503-421
See related: Ensembl:ENSDARG00000079818 AllianceGenome:ZFIN:ZDB-GENE-060503-421
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: hel308; si:ch211-85e10.2
Summary: Predicted to enable several functions, including ATP binding activity; helicase activity; and nucleic acid binding activity. Orthologous to human HELQ (helicase, POLQ like). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	21	NC_133196.1 (20677214..20694015)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (19330774..19347522)

Chromosome 21 - NC_133196.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: helicase POLQ-like

Names: helicase, mus308-like

NP_001269352.1

EC 3.6.4.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001282423.1 → NP_001269352.1 helicase POLQ-like

Status: PROVISIONAL

Source sequence(s)

BX649525

UniProtKB/TrEMBL

A0A8M1P553, F1Q4P2

Related

ENSDARP00000104305.2, ENSDART00000109412.4

Conserved Domains (4) summary

smart00490
Location:555 → 633

HELICc; helicase superfamily c-terminal domain

COG1204
Location:240 → 960

BRR2; Replicative superfamily II helicase [Replication, recombination and repair]

pfam00270
Location:266 → 427

DEAD; DEAD/DEAH box helicase

pfam14520
Location:930 → 983

HHH_5; Helix-hairpin-helix domain