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bmpr2a bone morphogenetic protein receptor, type II a (serine/threonine kinase) [ Danio rerio (zebrafish) ]

Gene ID: 562822, updated on 22-Nov-2020

Summary

Official Symbol
bmpr2aprovided by ZNC
Official Full Name
bone morphogenetic protein receptor, type II a (serine/threonine kinase)provided by ZNC
Primary source
ZFIN:ZDB-GENE-070618-1
See related
Ensembl:ENSDARG00000011941
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Orthologs

Genomic context

See bmpr2a in Genome Data Viewer
Location:
chromosome: 6
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (12795383..12851740, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (12562088..12616486, complement)
103 previous assembly Zv9 (GCF_000002035.4) 6 NC_007117.5 (12709568..12764223, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 15 member 1b Neighboring gene dedicator of cytokinesis 9b Neighboring gene family with sequence similarity 117 member Ba Neighboring gene islet cell autoantigen 1-like

Genomic regions, transcripts, and products

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transforming growth factor beta-activated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane receptor protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
determination of left/right symmetry IGI
Inferred from Genetic Interaction
more info
PubMed 
determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart jogging IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart looping IMP
Inferred from Mutant Phenotype
more info
PubMed 
lymph vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
notochord morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
sprouting angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
transmembrane receptor protein serine/threonine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
vasculature development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vasculature development IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
bone morphogenetic protein receptor type-2a; bone morphogenetic protein receptor, type II a (serine/threonine kinase)
Names
bone morphogenetic protein receptor type II a
bone morphogenetic protein receptor type IIa
NP_001034906.1
XP_005165892.1
XP_009300509.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039817.1NP_001034906.1  bone morphogenetic protein receptor type-2a precursor

    See identical proteins and their annotated locations for NP_001034906.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ002898
    UniProtKB/TrEMBL
    Q288P3
    Related
    ENSDARP00000056763.4, ENSDART00000056764.5
    Conserved Domains (3) summary
    smart00220
    Location:209499
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14054
    Location:212508
    STKc_BMPR2_AMHR2; Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors
    pfam01064
    Location:64134
    Activin_recp; Activin types I and II receptor domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    12795383..12851740 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005165835.4XP_005165892.1  bone morphogenetic protein receptor, type II a (serine/threonine kinase) isoform X1

    UniProtKB/TrEMBL
    A0A286YAW4
    Conserved Domains (3) summary
    smart00220
    Location:209499
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14054
    Location:212508
    STKc_BMPR2_AMHR2; Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors
    pfam01064
    Location:64134
    Activin_recp; Activin types I and II receptor domain
  2. XM_009302234.3XP_009300509.1  bone morphogenetic protein receptor, type II a (serine/threonine kinase) isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:156
    PKc_like; Protein Kinases, catalytic domain
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