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KYAT3 kynurenine aminotransferase 3 [ Homo sapiens (human) ]

Gene ID: 56267, updated on 9-Jul-2017
Official Symbol
KYAT3provided by HGNC
Official Full Name
kynurenine aminotransferase 3provided by HGNC
Primary source
HGNC:HGNC:33238
See related
Ensembl:ENSG00000137944 MIM:610656; Vega:OTTHUMG00000010617
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KAT3; CCBL2; KATIII
Summary
This gene encodes an aminotransferase that transaminates kynurenine to form kynurenic acid, which is a metabolite of tryptophan. Multiple alternatively spliced transcript variants that encode different proteins have been described for this gene. This gene shares 5' exon structure with the RNA binding motif protein, X-linked-like 1 locus on chromosome 1, but the coding sequences are non-overlapping. [provided by RefSeq, Mar 2017]
Orthologs
Location:
1p22.2
Exon count:
14
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (88935773..88992960, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (89401456..89458643, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene general transcription factor IIB Neighboring gene chromosome 20 open reading frame 196 pseudogene Neighboring gene RNA binding motif protein, X-linked like 1 Neighboring gene guanylate binding protein 3 Neighboring gene uncharacterized LOC105378841 Neighboring gene guanylate binding protein 1

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC9398, DKFZp547N1117, DKFZp667D0223

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
cysteine-S-conjugate beta-lyase activity IEA
Inferred from Electronic Annotation
more info
 
kynurenine-glyoxylate transaminase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
kynurenine-oxoglutarate transaminase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
2-oxoglutarate metabolic process IEA
Inferred from Electronic Annotation
more info
 
L-kynurenine metabolic process IEA
Inferred from Electronic Annotation
more info
 
biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
cellular amino acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
kynurenine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
kynurenine--oxoglutarate transaminase 3
Names
cysteine-S-conjugate beta-lyase 2
kynurenine aminotransferase III
kynurenine--glyoxylate transaminase
kynurenine--oxoglutarate transaminase III
NP_001008661.1
NP_001008662.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008661.2NP_001008661.1  kynurenine--oxoglutarate transaminase 3 isoform 1

    See identical proteins and their annotated locations for NP_001008661.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
    Source sequence(s)
    AI478599, AY028624, DC424120
    Consensus CDS
    CCDS30766.1
    UniProtKB/Swiss-Prot
    Q6YP21
    UniProtKB/TrEMBL
    B4DW13
    Related
    ENSP00000260508.4, OTTHUMP00000012359, ENST00000260508.8, OTTHUMT00000029300
    Conserved Domains (2) summary
    cd00609
    Location:66448
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
    PRK07777
    Location:44449
    PRK07777; aminotransferase; Validated
  2. NM_001008662.2NP_001008662.1  kynurenine--oxoglutarate transaminase 3 isoform 2

    See identical proteins and their annotated locations for NP_001008662.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' region and uses a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AI478599, AK057176, DC424120
    Consensus CDS
    CCDS30767.1
    UniProtKB/Swiss-Prot
    Q6YP21
    Related
    ENSP00000359522.3, OTTHUMP00000012357, ENST00000370491.7, OTTHUMT00000029297
    Conserved Domains (2) summary
    cd00609
    Location:32414
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
    PRK07777
    Location:10415
    PRK07777; aminotransferase; Validated
  3. NM_001349447.1NP_001336376.1  kynurenine--oxoglutarate transaminase 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks a segment in the 5' UTR, lacks an alternate exon in the 5' coding region, and initiates translation at a downstream start codon compared to variant 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AL139416, AL445991
  4. NM_001349448.1NP_001336377.1  kynurenine--oxoglutarate transaminase 3 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks a segment in the 5' UTR compared to variant 1. Variants 1 and 4 encode the same isoform (1).
    Source sequence(s)
    AL139416, AL445991
  5. NM_001349449.1NP_001336378.1  kynurenine--oxoglutarate transaminase 3 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has a shorter 5' UTR, lacks an exon in the 5' region and contains an alternate exon, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1. Variants 5 and 6 encode the same isoform (3).
    Source sequence(s)
    AL139416, AL445991
  6. NM_001349450.1NP_001336379.1  kynurenine--oxoglutarate transaminase 3 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has a shorter 5' UTR, contains an alternate exon in the 5' region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1. Variants 5 and 6 encode the same isoform (3).
    Source sequence(s)
    AI478599, AL833593, AY028624, DA943114

RNA

  1. NR_146183.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) is shorter at the 5' end and differs in the 3' exon structure compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated decay (NMD).
    Source sequence(s)
    AL139416, AL445991
  2. NR_146184.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated decay (NMD).
    Source sequence(s)
    AL139416, AL445991
  3. NR_146185.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) is shorter at the 5' end, lacks two internal exons and contains an alternate internal exon, and differs in the 3' exon structure compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated decay (NMD).
    Source sequence(s)
    AL139416, AL445991

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

    Range
    88935773..88992960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    89516514..89573685 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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