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CPXM1 carboxypeptidase X, M14 family member 1 [ Homo sapiens (human) ]

Gene ID: 56265, updated on 1-Jun-2020

Summary

Official Symbol
CPXM1provided by HGNC
Official Full Name
carboxypeptidase X, M14 family member 1provided by HGNC
Primary source
HGNC:HGNC:15771
See related
Ensembl:ENSG00000088882 MIM:609555
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPX1; CPXM
Summary
This gene likely encodes a member of the carboxypeptidase family of proteins. Cloning of a comparable locus in mouse indicates that the encoded protein contains a discoidin domain and a carboxypeptidase domain, but the protein appears to lack residues necessary for carboxypeptidase activity.[provided by RefSeq, May 2010]
Expression
Biased expression in endometrium (RPKM 64.0), gall bladder (RPKM 53.3) and 10 other tissues See more
Orthologs

Genomic context

See CPXM1 in Genome Data Viewer
Location:
20p13
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (2794074..2800627, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (2774715..2781292, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene EBF family member 4 Neighboring gene VISTA enhancer hs632 Neighboring gene ribosomal protein L19 pseudogene 1 Neighboring gene chromosome 20 open reading frame 141 Neighboring gene transmembrane protein 239

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
peptide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
probable carboxypeptidase X1
Names
carboxypeptidase X (M14 family), member 1
carboxypeptidase-like protein X1
metallocarboxypeptidase CPX-1
NP_001171628.1
NP_062555.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001184699.2NP_001171628.1  probable carboxypeptidase X1 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AI470029, AK315027, BC063430
    UniProtKB/Swiss-Prot
    Q96SM3
    Conserved Domains (4) summary
    cd11308
    Location:550626
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    smart00231
    Location:117274
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:116273
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl11393
    Location:295546
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
  2. NM_019609.5NP_062555.1  probable carboxypeptidase X1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_062555.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC063430, DB252546
    Consensus CDS
    CCDS13033.1
    UniProtKB/Swiss-Prot
    Q96SM3
    Related
    ENSP00000369979.2, ENST00000380605.3
    Conserved Domains (4) summary
    cd03869
    Location:295620
    M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
    cd11308
    Location:624700
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    smart00231
    Location:117274
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:116273
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    2794074..2800627 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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