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CPXM1 carboxypeptidase X, M14 family member 1 [ Homo sapiens (human) ]

Gene ID: 56265, updated on 27-Nov-2024

Summary

Official Symbol
CPXM1provided by HGNC
Official Full Name
carboxypeptidase X, M14 family member 1provided by HGNC
Primary source
HGNC:HGNC:15771
See related
Ensembl:ENSG00000088882 MIM:609555; AllianceGenome:HGNC:15771
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPX1; CPXM
Summary
This gene likely encodes a member of the carboxypeptidase family of proteins. Cloning of a comparable locus in mouse indicates that the encoded protein contains a discoidin domain and a carboxypeptidase domain, but the protein appears to lack residues necessary for carboxypeptidase activity.[provided by RefSeq, May 2010]
Expression
Biased expression in endometrium (RPKM 64.0), gall bladder (RPKM 53.3) and 10 other tissues See more
Orthologs
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Genomic context

See CPXM1 in Genome Data Viewer
Location:
20p13
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (2794074..2800627, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (2824548..2831102, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (2774720..2781273, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:2674597-2675581 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:2678055-2678598 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:2681405-2682133 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr20:2682134-2682861 Neighboring gene EBF family member 4 Neighboring gene VISTA enhancer hs632 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12605 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:2731029-2731709 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:2731778-2732289 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12606 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:2739980-2740630 Neighboring gene Sharpr-MPRA regulatory region 9456 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17471 Neighboring gene ribosomal protein L19 pseudogene 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:2778855-2779842 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:2779843-2780830 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:2780831-2781816 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12607 Neighboring gene CRISPRi-validated cis-regulatory element chr20.196 Neighboring gene chromosome 20 open reading frame 141 Neighboring gene transmembrane protein 239 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:2812614-2813114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17472 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:2820603-2821134 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:2821668-2822199 Neighboring gene PC-esterase domain containing 1A Neighboring gene VPS16 core subunit of CORVET and HOPS complexes

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metallocarboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
probable carboxypeptidase X1
Names
carboxypeptidase X (M14 family), member 1
carboxypeptidase-like protein X1
metallocarboxypeptidase CPX-1
NP_001171628.1
NP_062555.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001184699.2NP_001171628.1  probable carboxypeptidase X1 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AI470029, AK315027, BC063430
    UniProtKB/Swiss-Prot
    Q96SM3
    Conserved Domains (4) summary
    cd11308
    Location:550626
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    smart00231
    Location:117274
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:116273
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl11393
    Location:295546
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
  2. NM_019609.5NP_062555.1  probable carboxypeptidase X1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_062555.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC063430, DB252546
    Consensus CDS
    CCDS13033.1
    UniProtKB/Swiss-Prot
    Q6P4G8, Q6UW65, Q96SM3, Q9NUB5
    Related
    ENSP00000369979.2, ENST00000380605.3
    Conserved Domains (4) summary
    cd03869
    Location:295620
    M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
    cd11308
    Location:624700
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    smart00231
    Location:117274
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:116273
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    2794074..2800627 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    2824548..2831102 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)