Format

Send to:

Choose Destination

MEPCE methylphosphate capping enzyme [ Homo sapiens (human) ]

Gene ID: 56257, updated on 13-Mar-2020

Summary

Official Symbol
MEPCEprovided by HGNC
Official Full Name
methylphosphate capping enzymeprovided by HGNC
Primary source
HGNC:HGNC:20247
See related
Ensembl:ENSG00000146834 MIM:611478
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BCDIN3
Expression
Ubiquitous expression in testis (RPKM 29.4), spleen (RPKM 17.1) and 25 other tissues See more
Orthologs

Genomic context

See MEPCE in Genome Data Viewer
Location:
7q22.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (100428790..100434118)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100026321..100031749)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene STAG3L5P-PVRIG2P-PILRB readthrough Neighboring gene paired immunoglobin like type 2 receptor beta Neighboring gene paired immunoglobin like type 2 receptor alpha Neighboring gene zinc finger CW-type and PWWP domain containing 1 Neighboring gene PPP1R35 antisense RNA 1 Neighboring gene protein phosphatase 1 regulatory subunit 35 Neighboring gene CRISPRi-validated cis-regulatory element chr7.3510

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat A La-related protein, LARP7, is associated with P-TEFb, HEXIM1/2, MEPCE, and 7SK RNA in a large stable complex form. Knockdown of LARP7 decreases the steady-state level of 7SK, but increases free P-TEFb and enhances Tat-mediated transcription PubMed
tat HIV-1 Tat forms at least two distinct P-TEFb-containing complexes. Tatcom1 is composed of P-TEFb, AF9, ENL, ELL, AFF1, AFF4, and PAF1, presenting strong CTD-kinase activity, while Tatcom2 consists of 7SK, LARP7, and MEPCE with two molecules of Tat/P-TEFb PubMed
tat HIV-1 Tat complexes with LARP7, MEPCE, SART3, NPM1, PPM1G, hnRNP-F, and 7SK RNA to form a Tat-7SK RNP complex to control HIV-1 transcription PubMed
tat CDK9-CycT1-AFF1 is stimulated by HIV-1 Tat and transferred as a single complex unit to BRD4 upon stress-induced disruption of AFF1-containing 7SK snRNP (HEXIM1, MEPCE, LARP7, 7SK RNA, CDK9, CycT1, and AFF1) PubMed
tat HIV-1 Tat is identified to have a physical interaction with 7SK snRNA methylphosphate capping enzyme (MEPCE) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20257

Gene Ontology Provided by GOA

Function Evidence Code Pubs
O-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding HDA PubMed 
RNA methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
RNA methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
S-adenosylmethionine-dependent methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
RNA methylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of chromatin binding IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
snRNA metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
snRNA modification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
snRNA modification IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
7SK snRNA methylphosphate capping enzyme
Names
bicoid-interacting protein 3 homolog
bin3 homolog
bin3, bicoid-interacting 3, homolog
NP_001181919.1
NP_001181920.1
NP_001181921.1
NP_001350415.1
NP_062552.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001194990.2NP_001181919.1  7SK snRNA methylphosphate capping enzyme isoform B

    See identical proteins and their annotated locations for NP_001181919.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream AUG, compared to variant 1. The resulting protein (isoform B) has a shorter N-terminus, compared to isoform A. Variants 2, 3 and 4 encode the same isoform (B).
    Source sequence(s)
    AC092849, AK055964, CB152355
    Consensus CDS
    CCDS55136.1
    UniProtKB/Swiss-Prot
    Q7L2J0
    Related
    ENSP00000400875.1, ENST00000414441.5
    Conserved Domains (1) summary
    pfam06859
    Location:106214
    Bin3; Bicoid-interacting protein 3 (Bin3)
  2. NM_001194991.2NP_001181920.1  7SK snRNA methylphosphate capping enzyme isoform B

    See identical proteins and their annotated locations for NP_001181920.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream AUG, compared to variant 1. The resulting protein (isoform B) has a shorter N-terminus, compared to isoform A. Variants 2, 3 and 4 encode the same isoform (B).
    Source sequence(s)
    BC018935, CB152355, CD672398
    Consensus CDS
    CCDS55136.1
    UniProtKB/Swiss-Prot
    Q7L2J0
    Conserved Domains (1) summary
    pfam06859
    Location:106214
    Bin3; Bicoid-interacting protein 3 (Bin3)
  3. NM_001194992.2NP_001181921.1  7SK snRNA methylphosphate capping enzyme isoform B

    See identical proteins and their annotated locations for NP_001181921.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream AUG, compared to variant 1. The resulting protein (isoform B) has a shorter N-terminus, compared to isoform A. Variants 2, 3 and 4 encode the same isoform (B).
    Source sequence(s)
    AC092849, BC018935, BP217791
    Consensus CDS
    CCDS55136.1
    UniProtKB/Swiss-Prot
    Q7L2J0
    Conserved Domains (1) summary
    pfam06859
    Location:106214
    Bin3; Bicoid-interacting protein 3 (Bin3)
  4. NM_001363486.2NP_001350415.1  7SK snRNA methylphosphate capping enzyme isoform B

    Status: VALIDATED

    Source sequence(s)
    AC092849, AK055964, HY017414
    Consensus CDS
    CCDS55136.1
    Conserved Domains (1) summary
    pfam06859
    Location:106214
    Bin3; Bicoid-interacting protein 3 (Bin3)
  5. NM_019606.6NP_062552.2  7SK snRNA methylphosphate capping enzyme isoform A

    See identical proteins and their annotated locations for NP_062552.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (A).
    Source sequence(s)
    BC016396, BC018935
    Consensus CDS
    CCDS5693.1
    UniProtKB/Swiss-Prot
    Q7L2J0
    Related
    ENSP00000308546.2, ENST00000310512.4
    Conserved Domains (2) summary
    cd02440
    Location:446616
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    pfam06859
    Location:575683
    Bin3; Bicoid-interacting protein 3 (Bin3)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    100428790..100434118
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center