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SERTAD4 SERTA domain containing 4 [ Homo sapiens (human) ]

Gene ID: 56256, updated on 5-Jul-2025
Official Symbol
SERTAD4provided by HGNC
Official Full Name
SERTA domain containing 4provided by HGNC
Primary source
HGNC:HGNC:25236
See related
Ensembl:ENSG00000082497 AllianceGenome:HGNC:25236
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DJ667H12.2
Summary
Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Broad expression in endometrium (RPKM 2.8), salivary gland (RPKM 2.4) and 20 other tissues See more
Orthologs
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See SERTAD4 in Genome Data Viewer
Location:
1q32.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (210232796..210246631)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (209471480..209485315)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (210406141..210419976)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2477 Neighboring gene Sharpr-MPRA regulatory region 1786 Neighboring gene UTP25 small subunit processome component Neighboring gene NANOG hESC enhancer GRCh37_chr1:210048900-210049401 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:210068740-210069939 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:210071837-210072364 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_2736 Neighboring gene Sharpr-MPRA regulatory region 13960 Neighboring gene synaptotagmin 14 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:210166703-210167203 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_2861 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_2872 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_2922 Neighboring gene NANOG hESC enhancer GRCh37_chr1:210284477-210284996 Neighboring gene MPRA-validated peak677 silencer Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_2948 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:210406019-210406552 Neighboring gene SERTAD4 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:210411491-210412001 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:210424713-210425268 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:210425824-210426378 Neighboring gene Sharpr-MPRA regulatory region 1241 Neighboring gene ST13, Hsp70 interacting protein pseudogene 19 Neighboring gene long intergenic non-protein coding RNA 2602

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. KRAS mutation promotes the colonization of Fusobacterium nucleatum in colorectal cancer by down-regulating SERTAD4. Chen Y, et al. J Cell Mol Med, 2024 Oct. PMID 39462261, Free PMC Article
  2. I-mfa domain proteins specifically interact with SERTA domain proteins and repress their transactivating functions. Kusano S, et al. Biochimie, 2011 Sep. PMID 21664411
  3. An integrated workflow for charting the human interaction proteome: insights into the PP2A system. Glatter T, et al. Mol Syst Biol, 2009. PMID 19156129, Free PMC Article
  4. Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. Pilot-Storck F, et al. Mol Cell Proteomics, 2010 Jul. PMID 20368287, Free PMC Article
  5. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. Yao Z, et al. Mol Cell, 2017 Jan 19. PMID 28065597, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KRAS mutation promotes the colonization of Fusobacterium nucleatum in colorectal cancer by down-regulating SERTAD4.
    Title: KRAS mutation promotes the colonization of Fusobacterium nucleatum in colorectal cancer by down-regulating SERTAD4.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
SERTA domain-containing protein 4

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001354173.2 → NP_001341102.1  SERTA domain-containing protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AI808539, AL035414, BP342499

  2. NM_001375428.1 → NP_001362357.1  SERTA domain-containing protein 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL035414
    Consensus CDS
    CCDS1494.1
    UniProtKB/Swiss-Prot
    B2RD32, Q9NUC0
    Conserved Domains (1) summary
    pfam06031
    Location:108 → 142
    SERTA; SERTA motif

  3. NM_019605.5 → NP_062551.1  SERTA domain-containing protein 4 isoform 1

    See identical proteins and their annotated locations for NP_062551.1

    Status: VALIDATED

    Source sequence(s)
    AL035414, AW340609, BC012083, BP342499
    Consensus CDS
    CCDS1494.1
    UniProtKB/Swiss-Prot
    B2RD32, Q9NUC0
    Related
    ENSP00000355979.3, ENST00000367012.4
    Conserved Domains (1) summary
    pfam06031
    Location:108 → 142
    SERTA; SERTA motif

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    210232796..210246631
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425536.1 → XP_047281492.1  SERTA domain-containing protein 4 isoform X1

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_011332687.1 Reference GRCh38.p14 PATCHES

    Range
    12538..26373
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331662.1 → XP_054187637.1  SERTA domain-containing protein 4 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    209471480..209485315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337727.1 → XP_054193702.1  SERTA domain-containing protein 4 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NUC0.1 GenPept UniProtKB/Swiss-Prot:Q9NUC0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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