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bmp10 bone morphogenetic protein 10 [ Danio rerio (zebrafish) ]

Gene ID: 562533, updated on 9-Sep-2025
Official Symbol
bmp10provided by ZNC
Official Full Name
bone morphogenetic protein 10provided by ZNC
Primary source
ZFIN:ZDB-GENE-060526-211
See related
Ensembl:ENSDARG00000061769 AllianceGenome:ZFIN:ZDB-GENE-060526-211
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
bmp10b; si:dkey-13n15.5
Summary
Predicted to enable cytokine activity. Acts upstream of or within artery development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in liver and pericardial region. Used to study hereditary hemorrhagic telangiectasia. Orthologous to human BMP10 (bone morphogenetic protein 10). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
human mouse all
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See bmp10 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 5 NC_133180.1 (21942185..21945421)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 5 NC_007116.7 (21211088..21214323)

Chromosome 5 - NC_133180.1Genomic Context describing neighboring genes Neighboring gene CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 Neighboring gene Rho GTPase activating protein 25 Neighboring gene si:dkey-13n15.11 Neighboring gene uncharacterized LOC101886205 Neighboring gene uncharacterized LOC101884650 Neighboring gene butyrophilin-like protein 2

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Comparative population genomics reveals genetic basis underlying body size of domestic chickens. Wang MS, et al. J Mol Cell Biol, 2016 Dec. PMID 27744377
  2. bmp10 maintains cardiac function by regulating iron homeostasis. Hu R, et al. J Genet Genomics, 2024 Dec. PMID 39414074
  3. Blood flow regulates acvrl1 transcription via ligand-dependent Alk1 activity. Anzell AR, et al. Angiogenesis, 2024 Aug. PMID 38727966
  4. BMP and Notch Signaling Pathways differentially regulate Cardiomyocyte Proliferation during Ventricle Regeneration. Wang W, et al. Int J Biol Sci, 2021. PMID 34239346, Free PMC Article
  5. Hemodynamic-mediated endocardial signaling controls in vivo myocardial reprogramming. Gálvez-Santisteban M, et al. Elife, 2019 Jun 25. PMID 31237233, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BMP10-mediated ALK1 signaling is continuously required for vascular development and maintenance.
    Title: BMP10-mediated ALK1 signaling is continuously required for vascular development and maintenance.
  2. Circulating Bmp10 acts via Alk1 to limit endothelial cell number in nascent arteries.
    Title: Circulating Bmp10 acts through endothelial Alk1 to mediate flow-dependent arterial quiescence.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within artery development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in circulatory system development IEA
Inferred from Electronic Annotation
more info
  
involved_in tube morphogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
bone morphogenetic protein 10

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130600.1 → NP_001124072.1  bone morphogenetic protein 10

    See identical proteins and their annotated locations for NP_001124072.1

    Status: PROVISIONAL

    Source sequence(s)
    BC163861
    UniProtKB/TrEMBL
    A2BGK2, B3DKI5
    Related
    ENSDARP00000082925.4, ENSDART00000088492.5
    Conserved Domains (2) summary
    pfam00019
    Location:381 → 484
    TGF_beta; Transforming growth factor beta like domain
    pfam00688
    Location:75 → 300
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133180.1 Reference GRCz12tu Primary Assembly

    Range
    21942185..21945421
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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