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CRTAM cytotoxic and regulatory T cell molecule [ Homo sapiens (human) ]

Gene ID: 56253, updated on 8-Jul-2021

Summary

Official Symbol
CRTAMprovided by HGNC
Official Full Name
cytotoxic and regulatory T cell moleculeprovided by HGNC
Primary source
HGNC:HGNC:24313
See related
Ensembl:ENSG00000109943 MIM:612597
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD355
Summary
The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008 [PubMed 18329370]).[supplied by OMIM, Feb 2009]
Expression
Biased expression in lymph node (RPKM 4.2), spleen (RPKM 1.7) and 11 other tissues See more
Orthologs
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Genomic context

See CRTAM in Genome Data Viewer
Location:
11q24.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (122838419..122872643)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (122709208..122743351)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene glutamate-ammonia ligase pseudogene 3 Neighboring gene ubiquitin associated and SH3 domain containing B Neighboring gene junctional cadherin complex regulator Neighboring gene RNA, U4 small nuclear 23, pseudogene Neighboring gene ATP synthase peripheral stalk-membrane subunit b pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
NOT involved_in T cell mediated cytotoxicity IDA
Inferred from Direct Assay
more info
PubMed 
NOT involved_in activated T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell recognition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell recognition IDA
Inferred from Direct Assay
more info
PubMed 
involved_in detection of stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in detection of tumor cell IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in detection of tumor cell IDA
Inferred from Direct Assay
more info
PubMed 
involved_in establishment of T cell polarity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in lymphocyte migration into lymphoid organs ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of activated T cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interferon-gamma production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of natural killer cell mediated cytotoxicity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of CD8-positive, alpha-beta T cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of T cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in immunological synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cytotoxic and regulatory T-cell molecule
Names
class-I MHC-restricted T-cell-associated molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304782.2NP_001291711.1  cytotoxic and regulatory T-cell molecule isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AB209830, AF001622, AP004318, BC070266, DC305734
    Consensus CDS
    CCDS76489.1
    UniProtKB/Swiss-Prot
    O95727
    Related
    ENSP00000433728.1, ENST00000533709.1
  2. NM_019604.4NP_062550.2  cytotoxic and regulatory T-cell molecule isoform 1 precursor

    See identical proteins and their annotated locations for NP_062550.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB209830, AF001622, AP004318, BC070266
    Consensus CDS
    CCDS8437.1
    UniProtKB/Swiss-Prot
    O95727
    Related
    ENSP00000227348.4, ENST00000227348.9
    Conserved Domains (2) summary
    smart00410
    Location:24114
    IG_like; Immunoglobulin like
    cl11960
    Location:20114
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    122838419..122872643
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542900.2XP_011541202.1  cytotoxic and regulatory T-cell molecule isoform X1

    Conserved Domains (1) summary
    cl11960
    Location:2065
    Ig; Immunoglobulin domain
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