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anln anillin, actin binding protein [ Danio rerio (zebrafish) ]

Gene ID: 562517, updated on 9-Sep-2025
Official Symbol
anlnprovided by ZNC
Official Full Name
anillin, actin binding proteinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-4486
See related
Ensembl:ENSDARG00000060917 AllianceGenome:ZFIN:ZDB-GENE-030131-4486
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fb74d05; wu:fd10d09; wu:fi41f04; si:ch211-197n10.2
Summary
Acts upstream of or within asymmetric cell division; glomerular filtration; and glomerulus development. Predicted to be active in actomyosin contractile ring. Is expressed in brain; eye; optic cup; optic tectum; and retina. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 8. Orthologous to human ANLN (anillin, actin binding protein). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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See anln in Genome Data Viewer
Location:
chromosome: 19
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 19 NC_133194.1 (37887276..37904788, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 19 NC_007130.7 (35433155..35450667, complement)

Chromosome 19 - NC_133194.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 19B Neighboring gene adenylate kinase 2 Neighboring gene protein tyrosine phosphatase 4A2b Neighboring gene collagen, type VIII, alpha 2 Neighboring gene uncharacterized LOC141379153

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. The Human FSGS-Causing ANLN R431C Mutation Induces Dysregulated PI3K/AKT/mTOR/Rac1 Signaling in Podocytes. Hall G, et al. J Am Soc Nephrol, 2018 Aug. PMID 30002222, Free PMC Article
  2. The Zebrafish Anillin-eGFP Reporter Marks Late Dividing Retinal Precursors and Stem Cells Entering Neuronal Lineages. Cepero Malo M, et al. PLoS One, 2017. PMID 28107513, Free PMC Article
  3. Analysis of Single Nucleotide Variants in CRISPR-Cas9 Edited Zebrafish Exomes Shows No Evidence of Off-Target Inflation. Mooney MR, et al. Front Genet, 2019. PMID 31681410, Free PMC Article
  4. Asymmetric inheritance of the apical domain and self-renewal of retinal ganglion cell progenitors depend on Anillin function. Paolini A, et al. Development, 2015 Mar 1. PMID 25655700
  5. Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS. Gbadegesin RA, et al. J Am Soc Nephrol, 2014 Sep. PMID 24676636, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The study provides the in vivo evidence for the requirement of Anillin during asymmetric neurogenic divisions.
    Title: Asymmetric inheritance of the apical domain and self-renewal of retinal ganglion cell progenitors depend on Anillin function.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC158365

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in actomyosin contractile ring assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within asymmetric cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within glomerular basement membrane development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within glomerular filtration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within podocyte development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in septin ring organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in actomyosin contractile ring IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in bleb IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
anillin

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102676.2 → NP_001096146.2  anillin

    Status: VALIDATED

    Source sequence(s)
    JBMGRA010000019
    UniProtKB/TrEMBL
    A0A8M1NE25, A0AB32TBF8, F1QJH8
    Related
    ENSDARP00000102493.2, ENSDART00000113574.4
    Conserved Domains (4) summary
    cd01263
    Location:1016 → 1142
    PH_anillin; Anillin Pleckstrin homology (PH) domain
    pfam00169
    Location:1019 → 1138
    PH; PH domain
    pfam08174
    Location:835 → 985
    Anillin; Cell division protein anillin
    pfam16018
    Location:170 → 254
    Anillin_N; Anillin N-terminus

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133194.1 Reference GRCz12tu Primary Assembly

    Range
    37887276..37904788 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005159661.4 → XP_005159718.1  anillin isoform X1

    UniProtKB/TrEMBL
    A0A286Y917, A0A8M2B6G3, A0AB32TBF8
    Related
    ENSDARP00000143654.1, ENSDART00000179357.2
    Conserved Domains (4) summary
    cd01263
    Location:1034 → 1160
    PH_anillin; Anillin Pleckstrin homology (PH) domain
    pfam00169
    Location:1037 → 1156
    PH; PH domain
    pfam08174
    Location:835 → 985
    Anillin; Cell division protein anillin
    pfam16018
    Location:170 → 254
    Anillin_N; Anillin N-terminus
Nucleotide Protein Strain
Heading Accession and Version

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