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MRAP melanocortin 2 receptor accessory protein [ Homo sapiens (human) ]

Gene ID: 56246, updated on 3-May-2025
Official Symbol
MRAPprovided by HGNC
Official Full Name
melanocortin 2 receptor accessory proteinprovided by HGNC
Primary source
HGNC:HGNC:1304
See related
Ensembl:ENSG00000170262 MIM:609196; AllianceGenome:HGNC:1304
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B27; FALP; FGD2; GCCD2; MRAP1; C21orf61
Summary
This gene encodes a melanocortin receptor-interacting protein. The encoded protein regulates trafficking and function of the melanocortin 2 receptor in the adrenal gland. The encoded protein can also modulate signaling of other melanocortin receptors. Mutations in this gene have been associated with familial glucocorticoid deficiency type 2. Alternatively spliced transcript variants have been described. [provided by RefSeq, Dec 2009]
Expression
Broad expression in fat (RPKM 19.3), adrenal (RPKM 18.8) and 20 other tissues See more
Orthologs
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See MRAP in Genome Data Viewer
Location:
21q22.11
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (32291813..32314784)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (30661493..30684541)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (33664124..33687095)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene MIS18 kinetochore protein A Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:33650609-33651110 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:33651111-33651610 Neighboring gene MIS18A antisense RNA 1 Neighboring gene uncharacterized LOC124905009 Neighboring gene Sharpr-MPRA regulatory region 333 Neighboring gene MRAP antisense RNA 1 Neighboring gene NANOG hESC enhancer GRCh37_chr21:33702964-33703556 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:33706649-33707848 Neighboring gene URB1 ribosome biogenesis homolog Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18361 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:33754437-33755636 Neighboring gene H3K27ac hESC enhancers GRCh37_chr21:33764587-33765369 and GRCh37_chr21:33765370-33766151 Neighboring gene small nucleolar RNA, H/ACA box 80A Neighboring gene URB1 antisense RNA 1 (head to head)

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables corticotropin hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables corticotropin hormone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables type 1 melanocortin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables type 1 melanocortin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables type 3 melanocortin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables type 3 melanocortin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables type 4 melanocortin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables type 4 melanocortin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables type 5 melanocortin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables type 5 melanocortin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
melanocortin-2 receptor accessory protein
Names
fat cell-specific low molecular weight protein
fat tissue-specific low MW protein

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016234.1 RefSeqGene

    Range
    12043..25478
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001285394.2NP_001272323.1  melanocortin-2 receptor accessory protein isoform c

    See identical proteins and their annotated locations for NP_001272323.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks a coding exon compared to variant 1. The resulting isoform (c) has a shorter N-terminus compared to isoform alpha.
    Source sequence(s)
    AP000266
    UniProtKB/Swiss-Prot
    Q8TCY5
    Related
    ENST00000497833.1
    Conserved Domains (1) summary
    pfam15183
    Location:130
    MRAP; Melanocortin-2 receptor accessory protein family
  2. NM_001379228.1NP_001366157.1  melanocortin-2 receptor accessory protein isoform alpha

    Status: REVIEWED

    Source sequence(s)
    AP000266
    Consensus CDS
    CCDS13613.1
    UniProtKB/Swiss-Prot
    Q5EBR3, Q8TCY5, Q8TDB7, Q8WXC1, Q8WXC2
    Related
    ENSP00000306697.5, ENST00000303645.10
    Conserved Domains (1) summary
    pfam15183
    Location:189
    MRAP; Melanocortin-2 receptor accessory protein family
  3. NM_178817.4NP_848932.1  melanocortin-2 receptor accessory protein isoform alpha

    See identical proteins and their annotated locations for NP_848932.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (alpha).
    Source sequence(s)
    AP000266
    Consensus CDS
    CCDS13613.1
    UniProtKB/Swiss-Prot
    Q5EBR3, Q8TCY5, Q8TDB7, Q8WXC1, Q8WXC2
    Related
    ENSP00000382684.2, ENST00000399784.6
    Conserved Domains (1) summary
    pfam15183
    Location:189
    MRAP; Melanocortin-2 receptor accessory protein family
  4. NM_206898.2NP_996781.1  melanocortin-2 receptor accessory protein isoform beta

    See identical proteins and their annotated locations for NP_996781.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding region compared to variant 1. The resulting isoform (beta) is shorter and has a distinct C-terminus compared to isoform alpha.
    Source sequence(s)
    AF454915, AF483549
    Consensus CDS
    CCDS13612.1
    UniProtKB/Swiss-Prot
    Q8TCY5
    Related
    ENSP00000343661.4, ENST00000339944.4
    Conserved Domains (1) summary
    pfam15183
    Location:172
    MRAP; Melanocortin-2 receptor accessory protein family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    32291813..32314784
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    30661493..30684541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)