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EPCIP exosomal polycystin 1 interacting protein [ Homo sapiens (human) ]

Gene ID: 56245, updated on 1-Mar-2024

Summary

Official Symbol
EPCIPprovided by HGNC
Official Full Name
exosomal polycystin 1 interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:1305
See related
Ensembl:ENSG00000205929 AllianceGenome:HGNC:1305
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B37; CU062; PRED81; C21orf62; C21orf120
Expression
Biased expression in ovary (RPKM 6.0), kidney (RPKM 3.0) and 3 other tissues See more
Orthologs
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Genomic context

See EPCIP in Genome Data Viewer
Location:
21q22.11
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (32790673..32813703, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (31156897..31179935, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (34162984..34186013, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene synaptojanin 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:34100031-34100531 Neighboring gene PAXBP1 antisense RNA 1 Neighboring gene uncharacterized LOC124905010 Neighboring gene PAX3 and PAX7 binding protein 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:34143733-34144722 Neighboring gene EPCIP antisense RNA 1 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene uncharacterized LOC124905012 Neighboring gene VISTA enhancer hs1548

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in mitocytosis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in migrasome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
polycystin-1-interacting protein 1
Names
uncharacterized protein C21orf62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162495.3NP_001155967.2  polycystin-1-interacting protein 1 precursor

    See identical proteins and their annotated locations for NP_001155967.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AP000280, BC069689, BC069779, BE466137, DQ656042
    Consensus CDS
    CCDS42919.2
    UniProtKB/Swiss-Prot
    A8K4L8, Q9NYP8
    Related
    ENSP00000418653.1, ENST00000479548.2
    Conserved Domains (1) summary
    pfam15137
    Location:6219
    DUF4571; Domain of unknown function (DUF4571)
  2. NM_001162496.3NP_001155968.2  polycystin-1-interacting protein 1 precursor

    See identical proteins and their annotated locations for NP_001155968.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AP000280, BC069689, BC069709, BE466137, DQ656042
    Consensus CDS
    CCDS42919.2
    UniProtKB/Swiss-Prot
    A8K4L8, Q9NYP8
    Related
    ENSP00000418511.1, ENST00000487113.1
    Conserved Domains (1) summary
    pfam15137
    Location:6219
    DUF4571; Domain of unknown function (DUF4571)
  3. NM_019596.6NP_062542.5  polycystin-1-interacting protein 1 precursor

    See identical proteins and their annotated locations for NP_062542.5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AP000280, BC069689, BE466137, DQ656042
    Consensus CDS
    CCDS42919.2
    UniProtKB/Swiss-Prot
    A8K4L8, Q9NYP8
    Related
    ENSP00000418830.1, ENST00000490358.5
    Conserved Domains (1) summary
    pfam15137
    Location:6219
    DUF4571; Domain of unknown function (DUF4571)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    32790673..32813703 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003315969.2 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    21595..44610 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    31156897..31179935 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)