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kl klotho [ Danio rerio (zebrafish) ]

Gene ID: 562316, updated on 9-Sep-2025
Official Symbol
klprovided by ZNC
Official Full Name
klothoprovided by ZNC
Primary source
ZFIN:ZDB-GENE-110221-1
See related
Ensembl:ENSDARG00000079862 AllianceGenome:ZFIN:ZDB-GENE-110221-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable fibroblast growth factor binding activity and fibroblast growth factor receptor binding activity. Acts upstream of or within embryonic cleavage. Predicted to be located in membrane. Is expressed in several structures, including digestive system; gill; heart; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in coronary artery disease; intracranial embolism; and spondylosis. Orthologous to human KL (klotho). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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Location:
chromosome: 10
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 10 NC_133185.1 (39019534..39042799)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 10 NC_007121.7 (34001652..34021975)

Chromosome 10 - NC_133185.1Genomic Context describing neighboring genes Neighboring gene furry homolog b (Drosophila) Neighboring gene uncharacterized LOC141376423 Neighboring gene zygote arrest 1-like Neighboring gene serine protease HTRA2, mitochondrial-like Neighboring gene replication factor C (activator 1) 3

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Loss of αklotho causes reduced motor ability and short lifespan in zebrafish. Ogura Y, et al. Sci Rep, 2021 Jul 23. PMID 34301962, Free PMC Article
  2. Alignment of Alzheimer's disease amyloid β-peptide and klotho. Lehrer S, et al. World Acad Sci J, 2020 Nov-Dec. PMID 32999998, Free PMC Article
  3. Klotho Exerts an Emerging Role in Cytokinesis. Sun CY, et al. Genes (Basel), 2020 Sep 4. PMID 32899868, Free PMC Article
  4. Identification and expression analysis of the zebrafish orthologue of Klotho. Sugano Y, et al. Dev Genes Evol, 2011 Aug. PMID 21725870
  5. Molecular Physiology of the Hypocalcemic Action of Fibroblast Growth Factor 23 in Zebrafish (Danio rerio). Lin CH, et al. Endocrinology, 2017 May 1. PMID 28323996

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. study aimed to identify and characterize the orthologue of Klotho in zebrafish [klotho]
    Title: Identification and expression analysis of the zebrafish orthologue of Klotho.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables fibroblast growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fibroblast growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within embryonic cleavage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
klotho

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RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133185.1 Reference GRCz12tu Primary Assembly

    Range
    39019534..39042799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073915010.1 → XP_073771111.1  klotho isoform X1

    UniProtKB/TrEMBL
    A0A8N7TDV5

  2. XM_068218614.1 → XP_068074715.1  klotho isoform X2

    UniProtKB/TrEMBL
    A0AB32TFS8, A0AB32U2H7

  3. XM_073915012.1 → XP_073771113.1  klotho isoform X2

    UniProtKB/TrEMBL
    A0AB32TFS8, A0AB32U2H7
Nucleotide Protein Strain
Heading Accession and Version

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