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Thsd1 thrombospondin, type I, domain 1 [ Mus musculus (house mouse) ]

Gene ID: 56229, updated on 27-Jan-2018

Summary

Official Symbol
Thsd1provided by MGI
Official Full Name
thrombospondin, type I, domain 1provided by MGI
Primary source
MGI:MGI:1929096
See related
Ensembl:ENSMUSG00000031480 Vega:OTTMUSG00000027152
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmtsp; 4833423O18Rik
Expression
Broad expression in lung adult (RPKM 7.1), bladder adult (RPKM 3.0) and 25 other tissues See more
Orthologs

Genomic context

See Thsd1 in Genome Data Viewer
Location:
8; 8 A2
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (22225862..22261334)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (23348972..23370361)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 29878 Neighboring gene vacuolar protein sorting 36 Neighboring gene ribosomal protein L30, pseudogene 2 Neighboring gene transmembrane phosphatase with tensin homology Neighboring gene non-histone chromosomal protein HMG-14 pseudogene Neighboring gene solute carrier family 25 (mitochondrial carrier ornithine transporter), member 15

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
hematopoietic progenitor cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
thrombospondin type-1 domain-containing protein 1
Names
transmembrane molecule with thrombospondin module

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205253.1NP_001192182.1  thrombospondin type-1 domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001192182.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks an exon in the 5' coding region and uses a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus and lacks a predicted signal peptide, compared to isoform 1.
    Source sequence(s)
    AC121933, AK052555, BY075510
    Consensus CDS
    CCDS85512.1
    UniProtKB/TrEMBL
    A0A1B0GT60
    Related
    ENSMUSP00000148214.1, OTTMUSP00000077297, ENSMUST00000162447.1, OTTMUST00000067163
    Conserved Domains (1) summary
    smart00209
    Location:281330
    TSP1; Thrombospondin type 1 repeats
  2. NM_001293688.1NP_001280617.1  thrombospondin type-1 domain-containing protein 1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001280617.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC117665, AC121933, BC051957, BY075510
    Consensus CDS
    CCDS80862.1
    UniProtKB/TrEMBL
    G3XA27
    Related
    ENSMUSP00000125118.1, OTTMUSP00000033754, ENSMUST00000160585.1, OTTMUST00000067162
    Conserved Domains (1) summary
    PHA03307
    Location:402723
    PHA03307; transcriptional regulator ICP4; Provisional
  3. NM_019576.2NP_062522.1  thrombospondin type-1 domain-containing protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_062522.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC117665, AC121933
    Consensus CDS
    CCDS22172.1
    UniProtKB/Swiss-Prot
    Q9JM61
    UniProtKB/TrEMBL
    A0A0R4J0U4
    Related
    ENSMUSP00000067701.3, OTTMUSP00000033753, ENSMUST00000069828.9, OTTMUST00000067161
    Conserved Domains (1) summary
    smart00209
    Location:342391
    TSP1; Thrombospondin type 1 repeats

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

    Range
    22225862..22261334
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509174.3XP_006509237.1  thrombospondin type-1 domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006509237.1

    UniProtKB/Swiss-Prot
    Q9JM61
    UniProtKB/TrEMBL
    A0A0R4J0U4
    Conserved Domains (1) summary
    smart00209
    Location:342391
    TSP1; Thrombospondin type 1 repeats
  2. XM_006509177.3XP_006509240.1  thrombospondin type-1 domain-containing protein 1 isoform X3

  3. XM_006509173.3XP_006509236.1  thrombospondin type-1 domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006509236.1

    UniProtKB/Swiss-Prot
    Q9JM61
    UniProtKB/TrEMBL
    A0A0R4J0U4
    Conserved Domains (1) summary
    smart00209
    Location:342391
    TSP1; Thrombospondin type 1 repeats
  4. XM_006509175.3XP_006509238.1  thrombospondin type-1 domain-containing protein 1 isoform X2

    Conserved Domains (1) summary
    smart00209
    Location:342391
    TSP1; Thrombospondin type 1 repeats
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