Cited4 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cited4provided by MGI
Official Full Name: Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4provided by MGI
Primary source: MGI:MGI:1861694
See related: Ensembl:ENSMUSG00000070803 AllianceGenome:MGI:1861694
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mrg2; MRG-2
Summary: Enables transcription coactivator activity. Involved in response to estrogen. Acts upstream of or within positive regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and hemolymphoid system. Orthologous to human CITED4 (Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 4 D2.1; 4 56.52 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (120523760..120525017)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (120666563..120667820)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exercise-induced CITED4 expression is necessary for regional remodeling of cardiac microstructural tissue helicity.
Title: Exercise-induced CITED4 expression is necessary for regional remodeling of cardiac microstructural tissue helicity.
CITED4 Protects Against Adverse Remodeling in Response to Physiological and Pathological Stress.
Title: CITED4 Protects Against Adverse Remodeling in Response to Physiological and Pathological Stress.
results suggest that the Cited4 gene is related to cardiac differentiation and maintenance of proliferation capacity of embryonic stem cell-derived cardiomyocytes during in vitro cardiogenesis
Title: Cited4 is related to cardiogenic induction and maintenance of proliferation capacity of embryonic stem cell-derived cardiomyocytes during in vitro cardiogenesis.
Data (including data from knockout mice) suggest Cited4 and CBP/Crebbp are required for LH (luteinizing hormone) and MAP kinase signaling to trigger ovulation via regulation of gene expression and histone acetylation in pre-ovulatory follicles.
Title: CBP-CITED4 is required for luteinizing hormone-triggered target gene expression during ovulation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D4Dcr19 (e-PCR), detects polymorphism
- UniSTS:507692

AW742964 (e-PCR)
- UniSTS:208719

NoName (e-PCR)
- UniSTS:225158

NoName (e-PCR)
- UniSTS:548514

RH136400 (e-PCR)
- UniSTS:210390

Homology

Homologs of the Cited4 gene: The Cited4 gene is conserved in human, chimpanzee, cow, and rat.
Orthologs from Annotation Pipeline: 249 organisms have orthologs with human gene Cited4
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA-templated transcription	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IPI Inferred from Physical Interaction more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in response to estrogen	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cbp/p300-interacting transactivator 4

Names: msg1-related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.