nr3c2 nuclear receptor subfamily 3, group C, member 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nr3c2provided by ZNC
Official Full Name: nuclear receptor subfamily 3, group C, member 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-060531-23
See related: Ensembl:ENSDARG00000102082 AllianceGenome:ZFIN:ZDB-GENE-060531-23
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mr; si:ch211-189l17.1
Summary: Enables nuclear steroid receptor activity and steroid hormone binding activity. Acts upstream of or within cellular response to cortisol stimulus; multicellular organismal response to stress; and positive regulation of glucocorticoid receptor signaling pathway. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in several structures, including blood; heart; liver; male organism; and pleuroperitoneal region. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autosomal dominant pseudohypoaldosteronism type 1 and pseudohypoaldosteronism. Orthologous to human NR3C2 (nuclear receptor subfamily 3 group C member 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (36935154..37087966, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (36203197..36356009, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zebrafish Mutant Lines Reveal the Interplay between nr3c1 and nr3c2 in the GC-Dependent Regulation of Gene Transcription.
Title: Zebrafish Mutant Lines Reveal the Interplay between nr3c1 and nr3c2 in the GC-Dependent Regulation of Gene Transcription.
Glucocorticoid and mineralocorticoid receptor activation modulates postnatal growth.
Title: Glucocorticoid and mineralocorticoid receptor activation modulates postnatal growth.
Data demonstrate that there are distinct differences between the human mineralocorticoid receptor (MR) and the zebrafish MR despite considerable sequence and functional conservation.
Title: Characterization of the zebrafish (Danio rerio) mineralocorticoid receptor.

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General gene information

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Markers

G39287 (e-PCR)
- UniSTS:40298

fi12h11.x1 (e-PCR)
- UniSTS:196808

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables estrogen response element binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear steroid receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables steroid hormone binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to cortisol stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organismal response to stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in nuclear receptor-mediated steroid hormone signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of glucocorticoid receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to steroid hormone	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mineralocorticoid receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100403.1 → NP_001093873.1 mineralocorticoid receptor

See identical proteins and their annotated locations for NP_001093873.1

Status: PROVISIONAL

Source sequence(s)

EF567113

UniProtKB/TrEMBL

A0A8M1NFD6, A6YIH7, F1QVF6

Related

ENSDARP00000130941.1, ENSDART00000172111.2

Conserved Domains (3) summary

cd07075
Location:723 → 970

NR_LBD_MR; Ligand binding domain of the mineralocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:597 → 674

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:486 → 573

GCR; Glucocorticoid receptor