paox polyamine oxidase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: paoxprovided by ZNC
Official Full Name: polyamine oxidaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-090312-204
See related: Ensembl:ENSDARG00000003380 Ensembl:ENSDARG00000109596 AllianceGenome:ZFIN:ZDB-GENE-090312-204
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-275b16.2
Summary: Predicted to enable polyamine oxidase activity. Predicted to be involved in spermidine catabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human PAOX (polyamine oxidase). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 13

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	13	NC_133188.1 (34050095..34057486, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (30655172..30662403, complement)

Chromosome 13 - NC_133188.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fj13e08.x1 (e-PCR)
- UniSTS:188438

fc02h08.x1 (e-PCR)
- UniSTS:192089

fc25b11.y1 (e-PCR)
- UniSTS:193242

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables N(1)-acetylpolyamine oxidase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables polyamine oxidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in spermidine catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: peroxisomal N(1)-acetyl-spermine/spermidine oxidase

Names: polyamine oxidase (exo-N4-amino)

NP_001314981.1

EC 1.5.3.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001328052.1 → NP_001314981.1 peroxisomal N(1)-acetyl-spermine/spermidine oxidase

Status: VALIDATED

Source sequence(s)

BC155664, JBMGRA010000013

UniProtKB/TrEMBL

A0A8M1P8Q4, A9JRH7, B8JJQ4

Related

ENSDARP00000016209.6, ENSDART00000012457.7

Conserved Domains (1) summary

cl27535
Location:26 → 503

Amino_oxidase; Flavin containing amine oxidoreductase