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Rev1 REV1, DNA directed polymerase [ Mus musculus (house mouse) ]

Gene ID: 56210, updated on 11-Jun-2024

Summary

Official Symbol
Rev1provided by MGI
Official Full Name
REV1, DNA directed polymeraseprovided by MGI
Primary source
MGI:MGI:1929074
See related
Ensembl:ENSMUSG00000026082 AllianceGenome:MGI:1929074
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rev1l; 1110027I23Rik
Summary
Enables deoxycytidyl transferase activity. Acts upstream of or within error-prone translesion synthesis. Predicted to be located in nucleus. Orthologous to human REV1 (REV1 DNA directed polymerase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 8.2), CNS E14 (RPKM 7.3) and 27 other tissues See more
Orthologs
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Genomic context

See Rev1 in Genome Data Viewer
Location:
1 B; 1 16.46 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (38091867..38169191, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (38052786..38129921, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3269 Neighboring gene STARR-positive B cell enhancer ABC_E10006 Neighboring gene STARR-seq mESC enhancer starr_00688 Neighboring gene thioredoxin domain containing 9 Neighboring gene STARR-seq mESC enhancer starr_00689 Neighboring gene eukaryotic translation initiation factor 5B Neighboring gene predicted gene, 34448 Neighboring gene STARR-seq mESC enhancer starr_00690 Neighboring gene STARR-seq mESC enhancer starr_00691 Neighboring gene predicted gene 5099 Neighboring gene AF4/FMR2 family, member 3 Neighboring gene predicted gene 16150

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC66950

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables deoxycytidyl transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables deoxycytidyl transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in error-free translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in error-prone translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within error-prone translesion synthesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to UV ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DNA repair protein REV1
Names
REV1 homolog
rev1-like terminal deoxycytidyl transferase

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359287.1NP_001346216.1  DNA repair protein REV1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC114583
    Conserved Domains (3) summary
    cd01701
    Location:16333
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:666759
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd19318
    Location:516551
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1
  2. NM_001359288.1NP_001346217.1  DNA repair protein REV1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC114583
    Conserved Domains (3) summary
    cd12145
    Location:634727
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd19318
    Location:484519
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1
    cl28996
    Location:1301
    PolY; Y-family of DNA polymerases
  3. NM_019570.4NP_062516.2  DNA repair protein REV1 isoform 1

    See identical proteins and their annotated locations for NP_062516.2

    Status: VALIDATED

    Source sequence(s)
    AK048838, BC058093
    Consensus CDS
    CCDS14899.1
    UniProtKB/Swiss-Prot
    Q920Q2, Q9QXV2
    Related
    ENSMUSP00000027251.7, ENSMUST00000027251.12
    Conserved Domains (4) summary
    cd01701
    Location:346822
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:11551248
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd17719
    Location:48131
    BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
    cd19318
    Location:10051040
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    38091867..38169191 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255641.2XP_030111501.1  DNA repair protein REV1 isoform X3

    Conserved Domains (4) summary
    cd01701
    Location:346812
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:11451238
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd17719
    Location:48131
    BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
    cd19318
    Location:9951030
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1
  2. XM_036152478.1XP_036008371.1  DNA repair protein REV1 isoform X2

    Conserved Domains (4) summary
    cd01701
    Location:346821
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:11541247
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd17719
    Location:48131
    BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
    cd19318
    Location:10041039
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1
  3. XM_006496155.5XP_006496218.2  DNA repair protein REV1 isoform X3

    Conserved Domains (4) summary
    cd01701
    Location:346812
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:11451238
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd17719
    Location:48131
    BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
    cd19318
    Location:9951030
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1
  4. XM_036152474.1XP_036008367.1  DNA repair protein REV1 isoform X5

    Conserved Domains (4) summary
    cd01701
    Location:346779
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:11121205
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd17719
    Location:48131
    BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
    cd19318
    Location:962997
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1
  5. XM_006496154.5XP_006496217.2  DNA repair protein REV1 isoform X2

    Conserved Domains (4) summary
    cd01701
    Location:346821
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:11541247
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd17719
    Location:48131
    BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
    cd19318
    Location:10041039
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1
  6. XM_006496153.5XP_006496216.2  DNA repair protein REV1 isoform X1

    UniProtKB/Swiss-Prot
    Q920Q2, Q9QXV2
    Conserved Domains (4) summary
    cd01701
    Location:346822
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:11551248
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd17719
    Location:48131
    BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
    cd19318
    Location:10051040
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1
  7. XM_036152475.1XP_036008368.1  DNA repair protein REV1 isoform X1

    UniProtKB/Swiss-Prot
    Q920Q2, Q9QXV2
    Conserved Domains (4) summary
    cd01701
    Location:346822
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:11551248
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd17719
    Location:48131
    BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
    cd19318
    Location:10051040
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1
  8. XM_036152479.1XP_036008372.1  DNA repair protein REV1 isoform X2

    Conserved Domains (4) summary
    cd01701
    Location:346821
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:11541247
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd17719
    Location:48131
    BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
    cd19318
    Location:10041039
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1
  9. XM_030255639.2XP_030111499.1  DNA repair protein REV1 isoform X1

    UniProtKB/Swiss-Prot
    Q920Q2, Q9QXV2
    Conserved Domains (4) summary
    cd01701
    Location:346822
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:11551248
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd17719
    Location:48131
    BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
    cd19318
    Location:10051040
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1
  10. XM_006496156.4XP_006496219.1  DNA repair protein REV1 isoform X4

    Conserved Domains (4) summary
    cd01701
    Location:361837
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:11701263
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd17719
    Location:63146
    BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
    pfam14377
    Location:948969
    DUF4414; Domain of unknown function (DUF4414)
  11. XM_036152481.1XP_036008374.1  DNA repair protein REV1 isoform X7

    Conserved Domains (3) summary
    cd12145
    Location:634727
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd19318
    Location:484519
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1
    cl28996
    Location:1301
    PolY; Y-family of DNA polymerases
  12. XM_036152477.1XP_036008370.1  DNA repair protein REV1 isoform X1

    UniProtKB/Swiss-Prot
    Q920Q2, Q9QXV2
    Conserved Domains (4) summary
    cd01701
    Location:346822
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:11551248
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd17719
    Location:48131
    BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
    cd19318
    Location:10051040
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1
  13. XM_036152476.1XP_036008369.1  DNA repair protein REV1 isoform X1

    UniProtKB/Swiss-Prot
    Q920Q2, Q9QXV2
    Conserved Domains (4) summary
    cd01701
    Location:346822
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:11551248
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd17719
    Location:48131
    BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
    cd19318
    Location:10051040
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1
  14. XM_006496161.3XP_006496224.1  DNA repair protein REV1 isoform X6

    Conserved Domains (3) summary
    cd01701
    Location:16333
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:666759
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd19318
    Location:516551
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1
  15. XM_017321835.2XP_017177324.1  DNA repair protein REV1 isoform X7

    Conserved Domains (3) summary
    cd12145
    Location:634727
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd19318
    Location:484519
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1
    cl28996
    Location:1301
    PolY; Y-family of DNA polymerases
  16. XM_017321836.2XP_017177325.1  DNA repair protein REV1 isoform X6

    Conserved Domains (3) summary
    cd01701
    Location:16333
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:666759
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd19318
    Location:516551
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1
  17. XM_006496162.2XP_006496225.1  DNA repair protein REV1 isoform X7

    See identical proteins and their annotated locations for XP_006496225.1

    Conserved Domains (3) summary
    cd12145
    Location:634727
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd19318
    Location:484519
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1
    cl28996
    Location:1301
    PolY; Y-family of DNA polymerases
  18. XM_036152480.1XP_036008373.1  DNA repair protein REV1 isoform X6

    Related
    ENSMUST00000194650.6
    Conserved Domains (3) summary
    cd01701
    Location:16333
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:666759
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd19318
    Location:516551
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1
  19. XM_036152482.1XP_036008375.1  DNA repair protein REV1 isoform X7

    Conserved Domains (3) summary
    cd12145
    Location:634727
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd19318
    Location:484519
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1
    cl28996
    Location:1301
    PolY; Y-family of DNA polymerases