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Ensa endosulfine alpha [ Mus musculus (house mouse) ]

Gene ID: 56205, updated on 3-Apr-2024

Summary

Official Symbol
Ensaprovided by MGI
Official Full Name
endosulfine alphaprovided by MGI
Primary source
MGI:MGI:1891189
See related
Ensembl:ENSMUSG00000038619 AllianceGenome:MGI:1891189
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700020C18Rik; 2610007F17Rik
Summary
Predicted to enable potassium channel inhibitor activity; protein phosphatase inhibitor activity; and signaling receptor binding activity. Predicted to be involved in negative regulation of protein dephosphorylation. Predicted to act upstream of or within regulation of insulin secretion. Predicted to be active in cytoplasm. Is expressed in central nervous system; genitourinary system; retina; and skin. Orthologous to human ENSA (endosulfine alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 25.8), cortex adult (RPKM 23.6) and 28 other tissues See more
Orthologs
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Genomic context

See Ensa in Genome Data Viewer
Location:
3 F2.1; 3 40.74 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95532291..95539428)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95624980..95632117)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene golgi phosphoprotein 3-like Neighboring gene ribosomal protein S10, pseudogene 1 Neighboring gene CRISPRi-validated Mcl1 enhancer cluster Neighboring gene STARR-seq mESC enhancer starr_08389 Neighboring gene STARR-seq mESC enhancer starr_08391 Neighboring gene myeloid cell leukemia sequence 1 Neighboring gene STARR-seq mESC enhancer starr_08393 Neighboring gene ADAMTS-like 4 Neighboring gene STARR-seq mESC enhancer starr_08394 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:95511513-95511622 Neighboring gene microRNA 7014 Neighboring gene extracellular matrix protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables potassium channel inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein phosphatase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
alpha-endosulfine
Names
ARPP-19e

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001026212.1NP_001021383.1  alpha-endosulfine isoform b

    See identical proteins and their annotated locations for NP_001021383.1

    Status: VALIDATED

    Source sequence(s)
    AC092479, AK006149, AK011334
    Consensus CDS
    CCDS17617.1
    UniProtKB/Swiss-Prot
    P60840
    Related
    ENSMUSP00000045937.5, ENSMUST00000037983.6
    Conserved Domains (1) summary
    pfam04667
    Location:3386
    Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region
  2. NM_019561.2NP_062507.1  alpha-endosulfine isoform a

    See identical proteins and their annotated locations for NP_062507.1

    Status: VALIDATED

    Source sequence(s)
    AI451143, AK006149, AK011334
    Consensus CDS
    CCDS50993.1
    UniProtKB/Swiss-Prot
    P60840, Q5D069, Q6PBG4, Q9CQZ9, Q9Z0G1
    Related
    ENSMUSP00000051799.7, ENSMUST00000058230.13
    Conserved Domains (1) summary
    pfam04667
    Location:3386
    Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    95532291..95539428
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)