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FAM214A family with sequence similarity 214 member A [ Homo sapiens (human) ]

Gene ID: 56204, updated on 12-Oct-2019

Summary

Official Symbol
FAM214Aprovided by HGNC
Official Full Name
family with sequence similarity 214 member Aprovided by HGNC
Primary source
HGNC:HGNC:25609
See related
Ensembl:ENSG00000047346
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIAA1370
Expression
Ubiquitous expression in fat (RPKM 18.5), testis (RPKM 13.2) and 25 other tissues See more
Orthologs

Genomic context

See FAM214A in Genome Data Viewer
Location:
15q21.2-q21.3
Exon count:
18
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (52581321..52709817, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (52873518..52971569, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene myosin VA Neighboring gene eukaryotic translation elongation factor 1 beta 2 pseudogene 1 Neighboring gene cAMP regulated phosphoprotein 19 Neighboring gene uncharacterized LOC105370821 Neighboring gene uncharacterized LOC105370824 Neighboring gene one cut homeobox 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10980, KIAA1370, MGC126494, MGC126495

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286495.2NP_001273424.1  protein FAM214A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AB037791, AK293920, BC040548
    Consensus CDS
    CCDS66773.1
    UniProtKB/Swiss-Prot
    Q32MH5
    Related
    ENSP00000443598.2, ENST00000546305.6
    Conserved Domains (3) summary
    pfam13889
    Location:10251082
    Chromosome_seg; Chromosome segregation during meiosis
    pfam13915
    Location:885942
    DUF4210; Domain of unknown function (DUF4210)
    cl00262
    Location:477527
    TroA-like; Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between ...
  2. NM_019600.3NP_062546.2  protein FAM214A isoform 1

    See identical proteins and their annotated locations for NP_062546.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AB037791, BC040548, BC109128, DN990361
    Consensus CDS
    CCDS45263.1
    UniProtKB/Swiss-Prot
    Q32MH5
    Related
    ENSP00000261844.7, ENST00000261844.11
    Conserved Domains (4) summary
    pfam13889
    Location:10181074
    Chromosome_seg; Chromosome segregation during meiosis
    pfam13915
    Location:878935
    DUF4210; Domain of unknown function (DUF4210)
    cl00262
    Location:470520
    TroA-like; Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between ...
    cl25732
    Location:592788
    SMC_N; RecF/RecN/SMC N terminal domain

RNA

  1. NR_104457.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses alternate splice sites at the 5' terminal exon and at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB037791, AK293920, BC040548, DN990361
    Related
    ENST00000534964.6

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    52581321..52709817 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521789.2XP_011520091.1  protein FAM214A isoform X1

    See identical proteins and their annotated locations for XP_011520091.1

    UniProtKB/Swiss-Prot
    Q32MH5
    Conserved Domains (4) summary
    pfam13889
    Location:10181074
    Chromosome_seg; Chromosome segregation during meiosis
    pfam13915
    Location:878935
    DUF4210; Domain of unknown function (DUF4210)
    cl00262
    Location:470520
    TroA-like; Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between ...
    cl25732
    Location:592788
    SMC_N; RecF/RecN/SMC N terminal domain
  2. XM_005254548.2XP_005254605.1  protein FAM214A isoform X1

    See identical proteins and their annotated locations for XP_005254605.1

    UniProtKB/Swiss-Prot
    Q32MH5
    Conserved Domains (4) summary
    pfam13889
    Location:10181074
    Chromosome_seg; Chromosome segregation during meiosis
    pfam13915
    Location:878935
    DUF4210; Domain of unknown function (DUF4210)
    cl00262
    Location:470520
    TroA-like; Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between ...
    cl25732
    Location:592788
    SMC_N; RecF/RecN/SMC N terminal domain
  3. XM_024449990.1XP_024305758.1  protein FAM214A isoform X1

    Conserved Domains (4) summary
    pfam13889
    Location:10181074
    Chromosome_seg; Chromosome segregation during meiosis
    pfam13915
    Location:878935
    DUF4210; Domain of unknown function (DUF4210)
    cl00262
    Location:470520
    TroA-like; Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between ...
    cl25732
    Location:592788
    SMC_N; RecF/RecN/SMC N terminal domain
  4. XM_024449989.1XP_024305757.1  protein FAM214A isoform X1

    Related
    ENSP00000382153.4, ENST00000399202.8
    Conserved Domains (4) summary
    pfam13889
    Location:10181074
    Chromosome_seg; Chromosome segregation during meiosis
    pfam13915
    Location:878935
    DUF4210; Domain of unknown function (DUF4210)
    cl00262
    Location:470520
    TroA-like; Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between ...
    cl25732
    Location:592788
    SMC_N; RecF/RecN/SMC N terminal domain
  5. XM_005254547.2XP_005254604.1  protein FAM214A isoform X1

    See identical proteins and their annotated locations for XP_005254604.1

    UniProtKB/Swiss-Prot
    Q32MH5
    Conserved Domains (4) summary
    pfam13889
    Location:10181074
    Chromosome_seg; Chromosome segregation during meiosis
    pfam13915
    Location:878935
    DUF4210; Domain of unknown function (DUF4210)
    cl00262
    Location:470520
    TroA-like; Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between ...
    cl25732
    Location:592788
    SMC_N; RecF/RecN/SMC N terminal domain
  6. XM_011521790.2XP_011520092.1  protein FAM214A isoform X2

    Conserved Domains (3) summary
    pfam13889
    Location:10021059
    Chromosome_seg; Chromosome segregation during meiosis
    pfam13915
    Location:885942
    DUF4210; Domain of unknown function (DUF4210)
    cl00262
    Location:477527
    TroA-like; Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between ...
  7. XM_024449991.1XP_024305759.1  protein FAM214A isoform X1

    Related
    ENSP00000484641.1, ENST00000619572.4
    Conserved Domains (4) summary
    pfam13889
    Location:10181074
    Chromosome_seg; Chromosome segregation during meiosis
    pfam13915
    Location:878935
    DUF4210; Domain of unknown function (DUF4210)
    cl00262
    Location:470520
    TroA-like; Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between ...
    cl25732
    Location:592788
    SMC_N; RecF/RecN/SMC N terminal domain

RNA

  1. XR_001751360.1 RNA Sequence

  2. XR_001751359.1 RNA Sequence

  3. XR_001751358.1 RNA Sequence

  4. XR_001751357.1 RNA Sequence

  5. XR_001751356.1 RNA Sequence

  6. XR_931867.1 RNA Sequence

  7. XR_931866.2 RNA Sequence

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