U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abcb10 ATP-binding cassette, sub-family B member 10 [ Mus musculus (house mouse) ]

Gene ID: 56199, updated on 14-May-2024

Summary

Official Symbol
Abcb10provided by MGI
Official Full Name
ATP-binding cassette, sub-family B member 10provided by MGI
Primary source
MGI:MGI:1860508
See related
Ensembl:ENSMUSG00000031974 AllianceGenome:MGI:1860508
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Abc-me; Abcb12
Summary
This gene encodes a member of the ATP-binding cassette superfamily of transporters. ATP-binding cassette proteins transport various molecules across extra- and intra-cellular membranes. The encoded protein is localized to the mitochondrial inner membrane where it interacts with and stabilizes mitoferrin-1, and is important for heme biosynthesis. Additional evidence suggests the encoded protein is involved in oxidative stress protection and erythropoisesis. [provided by RefSeq, May 2013]
Expression
Broad expression in liver E14.5 (RPKM 58.9), liver E14 (RPKM 57.6) and 26 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Abcb10 in Genome Data Viewer
Location:
8 E2; 8 72.31 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (124679198..124709877, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (123952459..123983122, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29773 Neighboring gene actin alpha 1, skeletal muscle Neighboring gene nucleoporin 133 Neighboring gene predicted gene, 53469 Neighboring gene STARR-seq mESC enhancer starr_22990 Neighboring gene STARR-seq mESC enhancer starr_22991 Neighboring gene TATA-box binding protein associated factor 5 like Neighboring gene ribosomal protein L7A pseudogene Neighboring gene microRNA 1967 Neighboring gene URB2 ribosome biogenesis 2 homolog (S. cerevisiae)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ATP-binding cassette sub-family B member 10, mitochondrial
Names
ABC-mitochondrial erythroid protein
ATP-binding cassette transporter 10
ATP-binding cassette, sub-family B (MDR/TAP), member 10

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019552.2NP_062425.1  ATP-binding cassette sub-family B member 10, mitochondrial precursor

    See identical proteins and their annotated locations for NP_062425.1

    Status: REVIEWED

    Source sequence(s)
    BC054793
    Consensus CDS
    CCDS22766.1
    UniProtKB/Swiss-Prot
    Q542P7, Q9D0C7, Q9JI39
    Related
    ENSMUSP00000075011.7, ENSMUST00000075578.7
    Conserved Domains (3) summary
    cd03249
    Location:458698
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    TIGR00958
    Location:8694
    3a01208; Conjugate Transporter-2 (CT2) Family protein
    pfam00664
    Location:142403
    ABC_membrane; ABC transporter transmembrane region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    124679198..124709877 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154190.1XP_036010083.1  ATP-binding cassette sub-family B member 10, mitochondrial isoform X1

    Conserved Domains (3) summary
    cd03249
    Location:123363
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    cd07346
    Location:348
    ABC_6TM_exporters; TM helix 5 [structural motif]
    cl38913
    Location:395
    ABC_6TM_exporters; Six-transmembrane helical domain of the ATP-binding cassette transporters