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aplnra apelin receptor a [ Danio rerio (zebrafish) ]

Gene ID: 561935, updated on 18-Sep-2024

Summary

Official Symbol
aplnraprovided by ZNC
Official Full Name
apelin receptor aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060929-512
See related
Ensembl:ENSDARG00000002172 AllianceGenome:ZFIN:ZDB-GENE-060929-512
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
msr; Agtr1; agtrl1; APLNR2a; agtrl1a; zgc:152843
Summary
Enables apelin receptor activity. Involved in heart development. Acts upstream of with a positive effect on Kupffer's vesicle development. Acts upstream of or within with a positive effect on determination of heart left/right asymmetry and determination of liver left/right asymmetry. Acts upstream of or within gastrulation; regulation of nodal signaling pathway; and vasculature development. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including blastoderm; blastomere; cardiovascular system; immature eye; and mesoderm. Orthologous to human APLNR (apelin receptor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See aplnra in Genome Data Viewer
Location:
chromosome: 8
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (40325911..40327397, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (40286326..40287812, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene lysine (K)-specific demethylase 2Ba Neighboring gene ORAI calcium release-activated calcium modulator 1a Neighboring gene TBC1 domain family, member 10Aa Neighboring gene myosin, light chain 7, regulatory

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Clone Names

  • MGC66060, MGC152843

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables apelin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables apelin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_positive_effect Kupffer's vesicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within angioblast cell migration from lateral mesoderm to midline IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within angioblast cell migration from lateral mesoderm to midline IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in blood vessel development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cardiac muscle tissue development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within cell migration involved in gastrulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in coronary vasculature development ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within_positive_effect determination of heart left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of determination of left/right symmetry TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within_positive_effect determination of liver left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endodermal cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within epiboly involved in gastrulation with mouth forming second IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within gastrulation IEA
Inferred from Electronic Annotation
more info
 
involved_in gastrulation with mouth forming second ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in heart development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within heart development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in heart development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within lymph vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of cAMP-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of release of sequestered calcium ion into cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of nodal signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within sprouting angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in vasculogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
apelin receptor A
Names
G-protein coupled receptor APJ A
angiotensin II receptor-like 1a
angiotensin receptor-like 1
angiotensin receptor-like 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001075105.1NP_001068573.1  apelin receptor A

    See identical proteins and their annotated locations for NP_001068573.1

    Status: PROVISIONAL

    Source sequence(s)
    BC124150
    UniProtKB/Swiss-Prot
    Q002B2, Q08CP6, Q7SZP9
    UniProtKB/TrEMBL
    B2GPM9
    Related
    ENSDARP00000068614.4, ENSDART00000074125.6
    Conserved Domains (1) summary
    pfam00001
    Location:49314
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    40325911..40327397 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)