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malt1 MALT paracaspase 1 [ Danio rerio (zebrafish) ]

Gene ID: 561914, updated on 9-Sep-2025
Official Symbol
malt1provided by ZNC
Official Full Name
MALT paracaspase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-070705-156
See related
Ensembl:ENSDARG00000077768 AllianceGenome:ZFIN:ZDB-GENE-070705-156
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
malt1b; pcasp1; si:ch211-261c8.3
Summary
Predicted to enable endopeptidase activity. Predicted to be involved in proteolysis. Human ortholog(s) of this gene implicated in immunodeficiency 12; lymphoma; and non-Hodgkin lymphoma. Orthologous to human MALT1 (MALT1 paracaspase). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
human mouse all
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See malt1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 5 NC_133180.1 (72226017..72256071)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 5 NC_007116.7 (66312387..66340616)

Chromosome 5 - NC_133180.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 75 member 1 Neighboring gene prolactin receptor b Neighboring gene complexin 4b Neighboring gene embigin Neighboring gene huntingtin interacting protein 1 related b

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. MALT1 is not alone after all: identification of novel paracaspases. Hulpiau P, et al. Cell Mol Life Sci, 2016 Mar. PMID 26377317, Free PMC Article
  2. YTHDF2-mediated regulations bifurcate BHPF-induced programmed cell deaths. Lin J, et al. Natl Sci Rev, 2023 Dec. PMID 38152479, Free PMC Article
  3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
mucosa-associated lymphoid tissue lymphoma translocation protein 1
Names
MALT1 paracaspase b
mucosa associated lymphoid tissue lymphoma translocation gene 1b
paracaspase
paracaspase-1
pcasp1b

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RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133180.1 Reference GRCz12tu Primary Assembly

    Range
    72226017..72256071
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005165612.6 → XP_005165669.1  mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BCW4
    Conserved Domains (4) summary
    smart00410
    Location:113 → 188
    IG_like; Immunoglobulin like
    cd08783
    Location:11 → 106
    Death_MALT1; Death domain similar to that found in Mucosa-associated lymphoid tissue-lymphoma-translocation gene 1
    pfam00656
    Location:332 → 534
    Peptidase_C14; Caspase domain
    pfam13895
    Location:210 → 287
    Ig_2; Immunoglobulin domain

  2. XM_685317.9 → XP_690409.3  mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8N7TDU1
    Related
    ENSDARP00000099992.3
    Conserved Domains (4) summary
    smart00410
    Location:113 → 188
    IG_like; Immunoglobulin like
    cd08783
    Location:11 → 106
    Death_MALT1; Death domain similar to that found in Mucosa-associated lymphoid tissue-lymphoma-translocation gene 1
    pfam00656
    Location:307 → 509
    Peptidase_C14; Caspase domain
    pfam13895
    Location:210 → 287
    Ig_2; Immunoglobulin domain
Nucleotide Protein Strain
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