sema4c sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sema4cprovided by ZNC
Official Full Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Cprovided by ZNC
Primary source: ZFIN:ZDB-GENE-080303-16
See related: Ensembl:ENSDARG00000079611 AllianceGenome:ZFIN:ZDB-GENE-080303-16
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sc:d411
Summary: Predicted to enable chemorepellent activity; neuropilin binding activity; and semaphorin receptor binding activity. Acts upstream of or within motor neuron axon guidance. Predicted to be located in membrane. Predicted to be active in plasma membrane and synaptic vesicle membrane. Is expressed in several structures, including brain; cardiovascular system; lens placode; olfactory epithelium; and solid lens vesicle. Orthologous to human SEMA4C (semaphorin 4C). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	5	NC_133180.1 (15248896..15905652, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (14524328..14648276, complement)

Chromosome 5 - NC_133180.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

z99050 (e-PCR), detects polymorphism
- UniSTS:238735

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables chemorepellent activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropilin binding	IBA Inferred from Biological aspect of Ancestor more info
enables semaphorin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables semaphorin receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neural crest cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in semaphorin-plexin signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: semaphorin-4C

Names: semaphorin 4c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128246.1 → NP_001121718.1 semaphorin-4C precursor

See identical proteins and their annotated locations for NP_001121718.1

Status: PROVISIONAL

Source sequence(s)

CU458995

UniProtKB/TrEMBL

A0A8M2BFW5, A4JYS4, F1QF70

Related

ENSDARP00000098457.1, ENSDART00000113037.3

Conserved Domains (3) summary

cd11258
Location:40 → 497

Sema_4C; The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C)

pfam01437
Location:498 → 541

PSI; Plexin repeat

cl11960
Location:569 → 656

Ig; Immunoglobulin domain