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Hao2 hydroxyacid oxidase 2 [ Mus musculus (house mouse) ]

Gene ID: 56185, updated on 8-Feb-2024

Summary

Official Symbol
Hao2provided by MGI
Official Full Name
hydroxyacid oxidase 2provided by MGI
Primary source
MGI:MGI:96012
See related
Ensembl:ENSMUSG00000027870 AllianceGenome:MGI:96012
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hao3; Hao-2; Haox3
Summary
Predicted to enable (S)-2-hydroxy-acid oxidase activity; FMN binding activity; and identical protein binding activity. Predicted to be involved in fatty acid oxidation and mandelate metabolic process. Located in mitochondrion. Is expressed in several structures, including adrenal gland; genitourinary system; and nervous system. Orthologous to human HAO2 (hydroxyacid oxidase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 147.3), colon adult (RPKM 32.6) and 2 other tissues See more
Orthologs
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Genomic context

See Hao2 in Genome Data Viewer
Location:
3 F2.2; 3 42.9 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (98781835..98802692, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (98874519..98895376, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene 14-3-3 protein eta pseudogene Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Neighboring gene predicted gene, 31880 Neighboring gene predicted gene 12440

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables (S)-2-hydroxy-acid oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables (S)-2-hydroxy-acid oxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables FMN binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in fatty acid alpha-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in mandelate metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in peroxisomal matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in peroxisomal matrix ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
2-Hydroxyacid oxidase 2
Names
(S)-2-hydroxy-acid oxidase, peroxisomal
HAOX2
hydroxyacid oxidase (glycolate oxidase) 3
hydroxyacid oxidase 2, kidney
medium chain alpha-hydroxy acid oxidase
medium-chain 2-hydroxy acid oxidase HAOX3
medium-chain L-2-hydroxy acid oxidase
NP_062418.3
XP_011238471.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019545.4NP_062418.3  2-Hydroxyacid oxidase 2

    See identical proteins and their annotated locations for NP_062418.3

    Status: VALIDATED

    Source sequence(s)
    AF272947, AL671965, BB746253
    Consensus CDS
    CCDS17671.1
    UniProtKB/Swiss-Prot
    Q9JHS7, Q9JI00, Q9NYQ2
    UniProtKB/TrEMBL
    Q3UNU6, Q8JZR9, Q9D2W7
    Related
    ENSMUSP00000029464.8, ENSMUST00000029464.9
    Conserved Domains (1) summary
    pfam01070
    Location:14349
    FMN_dh; FMN-dependent dehydrogenase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    98781835..98802692 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240169.3XP_011238471.1  2-Hydroxyacid oxidase 2 isoform X1

    See identical proteins and their annotated locations for XP_011238471.1

    UniProtKB/Swiss-Prot
    Q9JHS7, Q9JI00, Q9NYQ2
    UniProtKB/TrEMBL
    Q3UNU6, Q8JZR9, Q9D2W7
    Conserved Domains (1) summary
    pfam01070
    Location:14349
    FMN_dh; FMN-dependent dehydrogenase