Nmu neuromedin U [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nmuprovided by MGI
Official Full Name: neuromedin Uprovided by MGI
Primary source: MGI:MGI:1860476
See related: Ensembl:ENSMUSG00000029236 AllianceGenome:MGI:1860476
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable type 1 neuromedin U receptor binding activity and type 2 neuromedin U receptor binding activity. Involved in several processes, including energy homeostasis; regulation of grooming behavior; and temperature homeostasis. Predicted to be located in extracellular region. Predicted to be active in terminal bouton. Is expressed in spinal cord; stomach; and testis. Human ortholog(s) of this gene implicated in obesity. Orthologous to human NMU (neuromedin U). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in stomach adult (RPKM 10.4), colon adult (RPKM 3.1) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 C3.3; 5 40.93 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (76481342..76511624, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (76333495..76363777, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuromedin U regulates the anti-tumor activity of CD8[+] T cells and glycolysis of tumor cells in the tumor microenvironment of pancreatic ductal adenocarcinoma in an NMUR1-dependent manner.
Title: Neuromedin U regulates the anti-tumor activity of CD8(+) T cells and glycolysis of tumor cells in the tumor microenvironment of pancreatic ductal adenocarcinoma in an NMUR1-dependent manner.
Neuromedin U programs eosinophils to promote mucosal immunity of the small intestine.
Title: Neuromedin U programs eosinophils to promote mucosal immunity of the small intestine.
Neuromedin U Induces Pulmonary ILC2 Activation via the NMUR1 Pathway during Acute Respiratory Syncytial Virus Infection.
Title: Neuromedin U Induces Pulmonary ILC2 Activation via the NMUR1 Pathway during Acute Respiratory Syncytial Virus Infection.
Nmu/Nms/Gpr176 Triple-Deficient Mice Show Enhanced Light-Resetting of Circadian Locomotor Activity.
Title: Nmu/Nms/Gpr176 Triple-Deficient Mice Show Enhanced Light-Resetting of Circadian Locomotor Activity.
Brain region-specific neuromedin U signalling regulates alcohol-related behaviours and food intake in rodents.
Title: Brain region-specific neuromedin U signalling regulates alcohol-related behaviours and food intake in rodents.
Neuromedin U (NMU) regulates osteoblast differentiation and activity.
Title: Neuromedin U (NMU) regulates osteoblast differentiation and activity.
Unlike NURP, icv injection of NMU significantly decreased the secretion of prolactin from the pituitary. NMU suppresses prolactin secretion via dopamine neurons of the arcuate nucleus
Title: Neuromedin U suppresses prolactin secretion via dopamine neurons of the arcuate nucleus.
These data indicate a novel role for the peripheral NMU system, providing new insights into the pathogenesis of NAFLD/NASH.
Title: Role of neuromedin U in accelerating of non-alcoholic steatohepatitis in mice.
Loss of NMU-NMUR1 signalling reduced ILC2 frequency and effector function, and altered transcriptional programs following allergen challenge in vivo. Thus, NMUR1 signalling promotes inflammatory ILC2 responses, highlighting the importance of neuro-immune crosstalk in allergic inflammation at mucosal surfaces.
Title: The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation.
NMU treatment in vivo resulted in immediate protective type 2 responses; accordingly, group 2 innate lymphoid cells -autonomous ablation of Nmur1 led to impaired type 2 responses and poor control of worm infection
Title: Neuronal regulation of type 2 innate lymphoid cells via neuromedin U.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (4)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:494180

NoName (e-PCR)
- UniSTS:485268

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables neuromedin U receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables neuromedin U receptor binding	ISO Inferred from Sequence Orthology more info	PubMed
enables type 1 neuromedin U receptor binding	ISO Inferred from Sequence Orthology more info
enables type 2 neuromedin U receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in eating behavior	ISO Inferred from Sequence Orthology more info
involved_in energy homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in energy homeostasis	ISO Inferred from Sequence Orthology more info
involved_in gastric acid secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of eating behavior	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gastric acid secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gastric emptying	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heat generation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of prolactin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stomach fundus smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian sleep/wake cycle, sleep	ISO Inferred from Sequence Orthology more info
involved_in regulation of feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of grooming behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of grooming behavior	ISO Inferred from Sequence Orthology more info
involved_in regulation of smooth muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in temperature homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in terminal bouton	IBA Inferred from Biological aspect of Ancestor more info
located_in terminal bouton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neuromedin-U

Names: neuromedin U precursor-related peptide/neuromedin U preproprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.