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Bace2 beta-site APP-cleaving enzyme 2 [ Mus musculus (house mouse) ]

Gene ID: 56175, updated on 12-May-2024

Summary

Official Symbol
Bace2provided by MGI
Official Full Name
beta-site APP-cleaving enzyme 2provided by MGI
Primary source
MGI:MGI:1860440
See related
Ensembl:ENSMUSG00000040605 AllianceGenome:MGI:1860440
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ARP1; ASP1; BAE2; DRAP; AEPLC; ALP56; ASP21; CDA13; CEAP1; 1110059C24Rik
Summary
This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein undergoes proteolytic processing to generate an active endopeptidase enzyme. This transmembrane protease catalyzes the proteolysis of amyloid precursor protein to produce amyloid beta peptide. Mice lacking the encoded product exhibit increased pancreatic beta cell mass and improved glucose tolerance due to increased insulin secretion. [provided by RefSeq, Jul 2016]
Expression
Biased expression in stomach adult (RPKM 52.5), colon adult (RPKM 18.7) and 8 other tissues See more
Orthologs
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Genomic context

See Bace2 in Genome Data Viewer
Location:
16 C4; 16 57.4 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (97157928..97244136)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (97356728..97442936)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene DS cell adhesion molecule Neighboring gene STARR-seq mESC enhancer starr_41622 Neighboring gene predicted gene, 32509 Neighboring gene VISTA enhancer mm1636 Neighboring gene predicted gene, 32432 Neighboring gene STARR-seq mESC enhancer starr_41625 Neighboring gene STARR-seq mESC enhancer starr_41626 Neighboring gene STARR-positive B cell enhancer mm9_chr16:97665487-97665787 Neighboring gene STARR-seq mESC enhancer starr_41629 Neighboring gene MX dynamin-like GTPase 1 Neighboring gene FAM3 metabolism regulating signaling molecule B Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (6)  1 citation

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables peptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in amyloid-beta metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in melanosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in melanosome organization ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane protein ectodomain proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of amyloid precursor protein biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in signaling receptor ligand precursor processing IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in signaling receptor ligand precursor processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in dense core granule ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in melanosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
beta-secretase 2
Names
aspartyl protease 1
beta-site amyloid precursor protein cleaving enzyme 2
memapsin-1
membrane-associated aspartic protease 1
theta-secretase
NP_062390.3
XP_006523131.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019517.5NP_062390.3  beta-secretase 2 preproprotein

    See identical proteins and their annotated locations for NP_062390.3

    Status: REVIEWED

    Source sequence(s)
    AC164088, AK034059, AK078770, AK165036, BB857972, BP765266
    Consensus CDS
    CCDS28359.1
    UniProtKB/Swiss-Prot
    Q3TNS7, Q8C5E9, Q8C793, Q9JL18, Q9R1P7
    UniProtKB/TrEMBL
    A0A0R4J0I8
    Related
    ENSMUSP00000043918.7, ENSMUST00000047275.8
    Conserved Domains (2) summary
    cd05473
    Location:85446
    beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease
    pfam00026
    Location:88425
    Asp; Eukaryotic aspartyl protease

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    97157928..97244136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523068.4XP_006523131.1  beta-secretase 2 isoform X1

    Conserved Domains (1) summary
    cl11403
    Location:1221
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases