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plcg2 phospholipase C, gamma 2 [ Danio rerio (zebrafish) ]

Gene ID: 561747, updated on 9-Sep-2025
Official Symbol
plcg2provided by ZNC
Official Full Name
phospholipase C, gamma 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9532
See related
Ensembl:ENSDARG00000068763 AllianceGenome:ZFIN:ZDB-GENE-030131-9532
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fj85b03; sb:eu1064; wu:fj85b03; zgc:152893; si:ch211-260p9.2
Summary
Predicted to enable phosphatidylinositol-4,5-bisphosphate phospholipase C activity. Predicted to be involved in phospholipid catabolic process. Predicted to act upstream of or within intracellular signal transduction and lipid metabolic process. Human ortholog(s) of this gene implicated in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. Orthologous to human PLCG2 (phospholipase C gamma 2). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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Location:
chromosome: 18
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 18 NC_133193.1 (14518579..14557015)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 18 NC_007129.7 (13248956..13293642)

Chromosome 18 - NC_133193.1Genomic Context describing neighboring genes Neighboring gene kelch-like family member 36 Neighboring gene coactosin-like F-actin binding protein 1 Neighboring gene MTOR associated protein, eak-7 homolog Neighboring gene si:ch211-260p9.3 Neighboring gene c-Maf inducing protein

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Candidate risk genes for bipolar disorder are highly conserved during evolution and highly interconnected. Franklin C, et al. Bipolar Disord, 2021 Jun. PMID 32959503
  2. Transcriptional profiling of angiogenesis activities of calycosin in zebrafish. Li S, et al. Mol Biosyst, 2011 Nov. PMID 21909574
  3. The Presence or Absence of Intestinal Microbiota Affects Lipid Deposition and Related Genes Expression in Zebrafish (Danio rerio). Sheng Y, et al. Front Microbiol, 2018. PMID 29896183, Free PMC Article
  4. Transforming Growth Factor β Drives Hemogenic Endothelium Programming and the Transition to Hematopoietic Stem Cells. Monteiro R, et al. Dev Cell, 2016 Aug 22. PMID 27499523, Free PMC Article
  5. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables lipase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4,5-bisphosphate phospholipase C activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
NP_001038433.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044968.2 → NP_001038433.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

    Status: PROVISIONAL

    Source sequence(s)
    JBMGRA010000018
    UniProtKB/TrEMBL
    A0A8M1N9W3, Q1LWV8
    Related
    ENSDARP00000075155.4, ENSDART00000080709.6
    Conserved Domains (8) summary
    cd00275
    Location:1044 → 1169
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08628
    Location:307 → 442
    PI-PLCc_gamma2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma2
    cd09932
    Location:631 → 734
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:516 → 617
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11969
    Location:762 → 816
    SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2
    cd13362
    Location:22 → 139
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cl14615
    Location:892 → 1017
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:826 → 893
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133193.1 Reference GRCz12tu Primary Assembly

    Range
    14518579..14557015
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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