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DNAH7 dynein axonemal heavy chain 7 [ Homo sapiens (human) ]

Gene ID: 56171, updated on 1-Aug-2020

Summary

Official Symbol
DNAH7provided by HGNC
Official Full Name
dynein axonemal heavy chain 7provided by HGNC
Primary source
HGNC:HGNC:18661
See related
Ensembl:ENSG00000118997 MIM:610061
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
DNAH7 is a component of the inner dynein arm of ciliary axonemes (Zhang et al., 2002 [PubMed 11877439]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in testis (RPKM 2.6), thyroid (RPKM 0.9) and 7 other tissues See more
Orthologs

Genomic context

See DNAH7 in Genome Data Viewer
Location:
2q32.3
Exon count:
68
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (195737604..196068837, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (196602427..196933536, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 member 10 Neighboring gene Sharpr-MPRA regulatory region 4685 Neighboring gene RNA, U6 small nuclear 915, pseudogene Neighboring gene uncharacterized LOC107985972 Neighboring gene uncharacterized LOC105373819 Neighboring gene glutathione S-transferase alpha 5 pseudogene Neighboring gene E2F transcription factor 3 pseudogene 2 Neighboring gene uncharacterized LOC101927454 Neighboring gene serine/threonine kinase 17b Neighboring gene HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 Neighboring gene HECW2 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37196, KIAA0944, MGC39580, DKFZp686C09101

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent microtubule motor activity, minus-end-directed IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule motor activity IC
Inferred by Curator
more info
PubMed 
microtubule motor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cilium movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cilium movement IMP
Inferred from Mutant Phenotype
more info
PubMed 
cilium-dependent cell motility NAS
Non-traceable Author Statement
more info
PubMed 
inner dynein arm assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
axonemal dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axonemal dynein complex NAS
Non-traceable Author Statement
more info
PubMed 
cilium IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inner dynein arm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inner dynein arm IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dynein heavy chain 7, axonemal
Names
axonemal beta dynein heavy chain 7
axonemal dynein heavy chain 7
ciliary dynein heavy chain 7
dynein heavy chain-like protein 2
dynein, axonemal, heavy polypeptide 7
hDHC2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018897.3NP_061720.2  dynein heavy chain 7, axonemal

    See identical proteins and their annotated locations for NP_061720.2

    Status: VALIDATED

    Source sequence(s)
    AC068919, AC114760, AF327442, BP199399, BX117789
    Consensus CDS
    CCDS42794.1
    UniProtKB/Swiss-Prot
    Q8WXX0
    Related
    ENSP00000311273.6, ENST00000312428.11
    Conserved Domains (5) summary
    pfam03028
    Location:33224012
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08393
    Location:7631162
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:25862933
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:29623178
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:12901520
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    195737604..196068837 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511488.3XP_011509790.1  dynein heavy chain 7, axonemal isoform X1

    Conserved Domains (5) summary
    pfam03028
    Location:32823972
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08393
    Location:7231122
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:25462893
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:29223138
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:12501480
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_017004504.2XP_016859993.1  dynein heavy chain 7, axonemal isoform X4

  3. XM_011511490.3XP_011509792.1  dynein heavy chain 7, axonemal isoform X3

    Conserved Domains (5) summary
    pfam03028
    Location:32473937
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08393
    Location:7631162
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:25112858
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:28873103
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:12901520
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. XM_011511489.2XP_011509791.1  dynein heavy chain 7, axonemal isoform X2

    Conserved Domains (5) summary
    pfam03028
    Location:32763966
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08393
    Location:7171116
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:25402887
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:29163132
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:12441474
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  5. XM_011511497.2XP_011509799.1  dynein heavy chain 7, axonemal isoform X10

    Conserved Domains (4) summary
    pfam03028
    Location:14462136
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam12777
    Location:7101057
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:10861302
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:427698
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  6. XM_011511491.3XP_011509793.1  dynein heavy chain 7, axonemal isoform X5

    Conserved Domains (4) summary
    pfam08393
    Location:7631162
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:25862933
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:29622981
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:12901520
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  7. XM_011511494.3XP_011509796.1  dynein heavy chain 7, axonemal isoform X8

    Conserved Domains (3) summary
    pfam08393
    Location:7631162
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:25862927
    MT; Microtubule-binding stalk of dynein motor
    cl21455
    Location:12901520
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  8. XM_011511493.3XP_011509795.1  dynein heavy chain 7, axonemal isoform X7

    Conserved Domains (3) summary
    pfam08393
    Location:7631162
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:25862928
    MT; Microtubule-binding stalk of dynein motor
    cl21455
    Location:12901520
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  9. XM_011511492.3XP_011509794.1  dynein heavy chain 7, axonemal isoform X6

    Conserved Domains (4) summary
    pfam08393
    Location:7631162
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:25862933
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:29622983
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:12901520
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  10. XM_011511495.3XP_011509797.1  dynein heavy chain 7, axonemal isoform X9

    Conserved Domains (3) summary
    pfam08393
    Location:7631162
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:25862798
    MT; Microtubule-binding stalk of dynein motor
    cl21455
    Location:12901520
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

  1. XR_922968.3 RNA Sequence

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