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TDRD1 tudor domain containing 1 [ Homo sapiens (human) ]

Gene ID: 56165, updated on 1-Jun-2020

Summary

Official Symbol
TDRD1provided by HGNC
Official Full Name
tudor domain containing 1provided by HGNC
Primary source
HGNC:HGNC:11712
See related
Ensembl:ENSG00000095627 MIM:605796
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT41.1
Summary
This gene encodes a protein containing a tudor domain that is thought to function in the suppression of transposable elements during spermatogenesis. The related protein in mouse forms a complex with piRNAs and Piwi proteins to promote methylation and silencing of target sequences. This gene was observed to be upregulated by ETS transcription factor ERG in prostate tumors. [provided by RefSeq, Sep 2018]
Expression
Biased expression in testis (RPKM 8.5) and prostate (RPKM 0.6) See more
Orthologs

Genomic context

See TDRD1 in Genome Data Viewer
Location:
10q25.3
Exon count:
30
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (114174442..114232669)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (115939015..115992425)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene UBE2V1 pseudogene 5 Neighboring gene coiled-coil domain containing 186 Neighboring gene microRNA 2110 Neighboring gene aurora kinase A pseudogene 2 Neighboring gene von Willebrand factor A domain containing 2 Neighboring gene actin filament associated protein 1 like 2 Neighboring gene uncharacterized LOC105378494

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21082

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA methylation involved in gamete generation ISS
Inferred from Sequence or Structural Similarity
more info
 
gene silencing by RNA ISS
Inferred from Sequence or Structural Similarity
more info
 
germ cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
piRNA metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
P granule ISS
Inferred from Sequence or Structural Similarity
more info
 
chromatoid body IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
pi-body ISS
Inferred from Sequence or Structural Similarity
more info
 
ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tudor domain-containing protein 1
Names
cancer/testis antigen 41.1
testicular tissue protein Li 193

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365891.2NP_001352820.1  tudor domain-containing protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022023, BX648664
    Conserved Domains (2) summary
    pfam00567
    Location:712832
    TUDOR; Tudor domain
    pfam01753
    Location:170206
    zf-MYND; MYND finger
  2. NM_198795.1NP_942090.1  tudor domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_942090.1

    Status: REVIEWED

    Source sequence(s)
    AK122916, BC035010, BQ882979, BX648664, CB136029
    Consensus CDS
    CCDS7588.1
    UniProtKB/Swiss-Prot
    Q9BXT4
    UniProtKB/TrEMBL
    A0A140VJW6
    Related
    ENSP00000251864.2, ENST00000251864.6
    Conserved Domains (3) summary
    cd04508
    Location:766813
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:712832
    TUDOR; Tudor domain
    pfam01753
    Location:170206
    zf-MYND; MYND finger

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    114174442..114232669
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539962.1XP_011538264.1  tudor domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011538264.1

    UniProtKB/Swiss-Prot
    Q9BXT4
    UniProtKB/TrEMBL
    A0A140VJW6
    Conserved Domains (3) summary
    cd04508
    Location:766813
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:712832
    TUDOR; Tudor domain
    pfam01753
    Location:170206
    zf-MYND; MYND finger
  2. XM_005269978.2XP_005270035.1  tudor domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005270035.1

    UniProtKB/Swiss-Prot
    Q9BXT4
    UniProtKB/TrEMBL
    A0A140VJW6
    Conserved Domains (3) summary
    cd04508
    Location:766813
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:712832
    TUDOR; Tudor domain
    pfam01753
    Location:170206
    zf-MYND; MYND finger
  3. XM_011539963.2XP_011538265.1  tudor domain-containing protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011538265.1

    UniProtKB/Swiss-Prot
    Q9BXT4
    Conserved Domains (3) summary
    cd04508
    Location:766813
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:712832
    TUDOR; Tudor domain
    pfam01753
    Location:170206
    zf-MYND; MYND finger
  4. XM_005269979.3XP_005270036.1  tudor domain-containing protein 1 isoform X5

    UniProtKB/TrEMBL
    H9KV63
    Related
    ENSP00000358288.1, ENST00000369282.5
    Conserved Domains (3) summary
    cd04508
    Location:766813
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:712832
    TUDOR; Tudor domain
    pfam01753
    Location:170206
    zf-MYND; MYND finger
  5. XM_024448081.1XP_024303849.1  tudor domain-containing protein 1 isoform X7

    Conserved Domains (2) summary
    pfam00567
    Location:655775
    TUDOR; Tudor domain
    pfam01753
    Location:170206
    zf-MYND; MYND finger
  6. XM_011539964.2XP_011538266.1  tudor domain-containing protein 1 isoform X4

    Conserved Domains (3) summary
    cd04508
    Location:709756
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:655775
    TUDOR; Tudor domain
    pfam01753
    Location:170206
    zf-MYND; MYND finger
  7. XM_017016414.2XP_016871903.1  tudor domain-containing protein 1 isoform X3

  8. XM_017016415.2XP_016871904.1  tudor domain-containing protein 1 isoform X6

  9. XM_011539959.2XP_011538261.1  tudor domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011538261.1

    UniProtKB/Swiss-Prot
    Q9BXT4
    UniProtKB/TrEMBL
    A0A140VJW6
    Conserved Domains (3) summary
    cd04508
    Location:766813
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:712832
    TUDOR; Tudor domain
    pfam01753
    Location:170206
    zf-MYND; MYND finger
  10. XM_011539960.2XP_011538262.1  tudor domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011538262.1

    UniProtKB/Swiss-Prot
    Q9BXT4
    UniProtKB/TrEMBL
    A0A140VJW6
    Conserved Domains (3) summary
    cd04508
    Location:766813
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:712832
    TUDOR; Tudor domain
    pfam01753
    Location:170206
    zf-MYND; MYND finger
  11. XM_011539961.2XP_011538263.1  tudor domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011538263.1

    UniProtKB/Swiss-Prot
    Q9BXT4
    UniProtKB/TrEMBL
    A0A140VJW6
    Conserved Domains (3) summary
    cd04508
    Location:766813
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:712832
    TUDOR; Tudor domain
    pfam01753
    Location:170206
    zf-MYND; MYND finger
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