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RNF17 ring finger protein 17 [ Homo sapiens (human) ]

Gene ID: 56163, updated on 1-Jun-2020

Summary

Official Symbol
RNF17provided by HGNC
Official Full Name
ring finger protein 17provided by HGNC
Primary source
HGNC:HGNC:10060
See related
Ensembl:ENSG00000132972 MIM:605793
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TDRD4; Mmip-2; SPATA23
Summary
This gene is similar to a mouse gene that encodes a testis-specific protein containing a RING finger domain. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, May 2010]
Expression
Restricted expression toward testis (RPKM 10.4) See more
Orthologs

Genomic context

See RNF17 in Genome Data Viewer
Location:
13q12.12
Exon count:
44
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (24747641..24888816)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (25338301..25454059)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 20 family member A10, pseudogene Neighboring gene uncharacterized LOC112268115 Neighboring gene clustered mitochondria homolog pseudogene 9 Neighboring gene iroquois homeobox 1 pseudogene 1 Neighboring gene centromere protein J Neighboring gene uncharacterized LOC107987187 Neighboring gene transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 1 Neighboring gene solute carrier family 25 member 15 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11045

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
spermatid development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
RING finger protein 17
Names
spermatogenesis associated 23
tudor domain containing 4
tudor domain-containing protein 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001184993.2NP_001171922.1  RING finger protein 17 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AK302435, BC037275
    UniProtKB/TrEMBL
    B7Z7S1
    Conserved Domains (2) summary
    cd04508
    Location:731776
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:11731291
    TUDOR; Tudor domain
  2. NM_031277.3NP_112567.2  RING finger protein 17 isoform 1

    See identical proteins and their annotated locations for NP_112567.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK001907, BC037275, CD358307, DB517763
    Consensus CDS
    CCDS9308.2
    UniProtKB/Swiss-Prot
    Q9BXT8
    Related
    ENSP00000255324.5, ENST00000255324.10
    Conserved Domains (2) summary
    cd04508
    Location:731776
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:11771295
    TUDOR; Tudor domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    24747641..24888816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535156.2XP_011533458.1  RING finger protein 17 isoform X1

    See identical proteins and their annotated locations for XP_011533458.1

    Conserved Domains (2) summary
    cd04508
    Location:15601607
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:12531371
    TUDOR; Tudor domain
  2. XM_011535152.2XP_011533454.1  RING finger protein 17 isoform X1

    See identical proteins and their annotated locations for XP_011533454.1

    Conserved Domains (2) summary
    cd04508
    Location:15601607
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:12531371
    TUDOR; Tudor domain
  3. XM_011535158.2XP_011533460.1  RING finger protein 17 isoform X5

    Conserved Domains (2) summary
    cd04508
    Location:15181565
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:12531371
    TUDOR; Tudor domain
  4. XM_011535157.2XP_011533459.1  RING finger protein 17 isoform X2

    Conserved Domains (2) summary
    cd04508
    Location:15561603
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:12491367
    TUDOR; Tudor domain
  5. XM_011535159.2XP_011533461.1  RING finger protein 17 isoform X6

    Conserved Domains (2) summary
    cd04508
    Location:758803
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:12041322
    TUDOR; Tudor domain
  6. XM_011535160.2XP_011533462.1  RING finger protein 17 isoform X7

    Conserved Domains (2) summary
    cd04508
    Location:758803
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:12001318
    TUDOR; Tudor domain
  7. XM_011535155.2XP_011533457.1  RING finger protein 17 isoform X1

    See identical proteins and their annotated locations for XP_011533457.1

    Conserved Domains (2) summary
    cd04508
    Location:15601607
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:12531371
    TUDOR; Tudor domain
  8. XM_006719846.3XP_006719909.1  RING finger protein 17 isoform X3

    Conserved Domains (2) summary
    cd04508
    Location:15531600
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:12461364
    TUDOR; Tudor domain
  9. XM_006719849.2XP_006719912.1  RING finger protein 17 isoform X4

    Conserved Domains (2) summary
    cd04508
    Location:15331580
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:12261344
    TUDOR; Tudor domain
  10. XM_006719852.2XP_006719915.1  RING finger protein 17 isoform X9

    Conserved Domains (2) summary
    cd04508
    Location:13921439
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:10851203
    TUDOR; Tudor domain
  11. XM_017020676.1XP_016876165.1  RING finger protein 17 isoform X8

  12. XM_011535162.1XP_011533464.1  RING finger protein 17 isoform X10

    Conserved Domains (2) summary
    cd04508
    Location:13591406
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:10521170
    TUDOR; Tudor domain
  13. XM_011535163.1XP_011533465.1  RING finger protein 17 isoform X11

    Conserved Domains (2) summary
    cd04508
    Location:11221169
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:815933
    TUDOR; Tudor domain
  14. XM_011535164.2XP_011533466.1  RING finger protein 17 isoform X12

    Related
    ENSP00000388892.1, ENST00000418120.5
    Conserved Domains (2) summary
    cd04508
    Location:750797
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:443561
    TUDOR; Tudor domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_031994.1: Suppressed sequence

    Description
    NM_031994.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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