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NSMCE3 NSE3 homolog, SMC5-SMC6 complex component [ Homo sapiens (human) ]

Gene ID: 56160, updated on 10-Oct-2019

Summary

Official Symbol
NSMCE3provided by HGNC
Official Full Name
NSE3 homolog, SMC5-SMC6 complex componentprovided by HGNC
Primary source
HGNC:HGNC:7677
See related
Ensembl:ENSG00000185115 MIM:608243
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCA4; LICS; NSE3; NDNL2; MAGEG1; MAGEL3
Summary
The protein encoded by this gene is part of the SMC5-6 chromatin reorganizing complex and is a member of the MAGE superfamily. This is an intronless gene. [provided by RefSeq, May 2011]
Orthologs

Genomic context

See NSMCE3 in Genome Data Viewer
Location:
15q13.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (29264989..29269822, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (29560353..29562020, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene amyloid beta precursor protein binding family A member 2 Neighboring gene family with sequence similarity 189 member A1 Neighboring gene DDB1 and CUL4 associated factor 6 pseudogene Neighboring gene Sharpr-MPRA regulatory region 3573 Neighboring gene uncharacterized LOC100130111 Neighboring gene tubulin beta class I pseudogene 8

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA recombination IEA
Inferred from Electronic Annotation
more info
 
DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to UV IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to hydroxyurea IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
regulation of growth IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Smc5-Smc6 complex IDA
Inferred from Direct Assay
more info
PubMed 
chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
non-structural maintenance of chromosomes element 3 homolog
Names
MAGE-G1 antigen
hepatocellular carcinoma-associated protein 4
hepatocellular carcinoma-associated protein HCA4
melanoma antigen, family G, 1
melanoma-associated antigen G1
necdin-like 2, SMC5-SMC6 complex component
necdin-like gene 2
necdin-like protein 2
non-SMC element 3 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053143.1 RefSeqGene

    Range
    5008..9841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138704.4NP_619649.1  non-structural maintenance of chromosomes element 3 homolog

    See identical proteins and their annotated locations for NP_619649.1

    Status: REVIEWED

    Source sequence(s)
    AC061965, AU310582, BC053999
    Consensus CDS
    CCDS10023.1
    UniProtKB/Swiss-Prot
    Q96MG7
    Related
    ENSP00000330694.4, ENST00000332303.6
    Conserved Domains (1) summary
    pfam01454
    Location:92261
    MAGE; MAGE family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    29264989..29269822 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_011332701.1 Reference GRCh38.p13 PATCHES

    Range
    1428056..1432889 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_187660.1 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    1540540..1545373 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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