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NSMCE3 NSE3 homolog, SMC5-SMC6 complex component [ Homo sapiens (human) ]

Gene ID: 56160, updated on 6-Nov-2022

Summary

Official Symbol
NSMCE3provided by HGNC
Official Full Name
NSE3 homolog, SMC5-SMC6 complex componentprovided by HGNC
Primary source
HGNC:HGNC:7677
See related
Ensembl:ENSG00000185115 MIM:608243; AllianceGenome:HGNC:7677
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCA4; LICS; NSE3; NDNL2; MAGEG1; MAGEL3
Summary
The protein encoded by this gene is part of the SMC5-6 chromatin reorganizing complex and is a member of the MAGE superfamily. This is an intronless gene. [provided by RefSeq, May 2011]
Orthologs
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Genomic context

See NSMCE3 in Genome Data Viewer
Location:
15q13.1
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (29264989..29269822, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (27043359..27048192, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (29557193..29562026, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene amyloid beta precursor protein binding family A member 2 Neighboring gene endosomal transmembrane epsin interactor 2 Neighboring gene DDB1 and CUL4 associated factor 6 pseudogene Neighboring gene Sharpr-MPRA regulatory region 3573 Neighboring gene tubulin beta class I pseudogene 8 Neighboring gene lung cancer immune cell infiltration associated lncRNA

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of Smc5-Smc6 complex IC
Inferred by Curator
more info
PubMed 
part_of Smc5-Smc6 complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, telomeric region IC
Inferred by Curator
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
non-structural maintenance of chromosomes element 3 homolog
Names
MAGE-G1 antigen
hepatocellular carcinoma-associated protein 4
hepatocellular carcinoma-associated protein HCA4
melanoma antigen, family G, 1
melanoma-associated antigen G1
necdin-like 2, SMC5-SMC6 complex component
necdin-like gene 2
necdin-like protein 2
non-SMC element 3 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053143.1 RefSeqGene

    Range
    5008..9841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138704.4NP_619649.1  non-structural maintenance of chromosomes element 3 homolog

    See identical proteins and their annotated locations for NP_619649.1

    Status: REVIEWED

    Source sequence(s)
    AC061965, AU310582, BC053999
    Consensus CDS
    CCDS10023.1
    UniProtKB/Swiss-Prot
    Q96MG7, Q9H214
    Related
    ENSP00000330694.4, ENST00000332303.6

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    29264989..29269822 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_011332701.1 Reference GRCh38.p14 PATCHES

    Range
    1428056..1432889 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_187660.1 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    1540540..1545373 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    27043359..27048192 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)