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PRKY protein kinase Y-linked (pseudogene) [ Homo sapiens (human) ]

Gene ID: 5616, updated on 25-Nov-2025
Official Symbol
PRKYprovided by HGNC
Official Full Name
protein kinase Y-linked (pseudogene)provided by HGNC
Primary source
HGNC:HGNC:9444
See related
Ensembl:ENSG00000293442 MIM:400008; AllianceGenome:HGNC:9444
Gene type
pseudo
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRKYP; PRKXP3
Summary
This gene is similar to the protein kinase, X-linked gene in the pseudoautosomal region of the X chromosome. The gene is classified as a transcribed pseudogene because it has lost a coding exon that results in all transcripts being candidates for nonsense-mediated decay (NMD) and unlikely to express a protein. Abnormal recombination between this gene and a related gene on chromosome X is a frequent cause of XX males and XY females. [provided by RefSeq, Jul 2010]
Expression
Broad expression in skin (RPKM 2.8), prostate (RPKM 1.9) and 19 other tissues See more
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See PRKY in Genome Data Viewer
Location:
Yp11.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (7273972..7381547)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (6926299..7033870)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (7142013..7249588)

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene transducin beta like 1 Y-linked Neighboring gene family with sequence similarity 199, Y-linked, pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chrY:6931456-6932655 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrY:6975278-6976477 Neighboring gene G protein-coupled receptor 143 Y-linked pseudogene Neighboring gene RN7SK pseudogene 282 Neighboring gene RNA, U6 small nuclear 941, pseudogene Neighboring gene RNA, U6 small nuclear 521, pseudogene Neighboring gene uncharacterized LOC107987338

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Promoter hypermethylation of Y-chromosome gene PRKY as a potential biomarker for the early diagnosis of prostate cancer. Dai Z, et al. Epigenomics, 2024. PMID 38979582, Free PMC Article
  2. A selective difference between human Y-chromosomal DNA haplotypes. Jobling MA, et al. Curr Biol, 1998 Dec 17-31. PMID 9889101
  3. High-resolution fluorescence in situ hybridization of human Y-linked genes on released chromatin. Gläser B, et al. Chromosome Res, 1997 Feb. PMID 9088640
  4. Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females. Schiebel K, et al. Hum Mol Genet, 1997 Oct. PMID 9302280
  5. The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability. Klink A, et al. Hum Mol Genet, 1995 May. PMID 7633447

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Promoter hypermethylation of Y-chromosome gene PRKY as a potential biomarker for the early diagnosis of prostate cancer.
    Title: Promoter hypermethylation of Y-chromosome gene PRKY as a potential biomarker for the early diagnosis of prostate cancer.
  2. Observational study of genetic testing. (HuGE Navigator)
    Title: Perioperative genomic profiles using structure-specific oligonucleotide probes.
Submit: New GeneRIF Correction

Review eQTL and phenotype association data in this region using PheGenI

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cAMP-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of cAMP-dependent protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_028062.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AA767129, AC007284, AC010143, BC074852, Y15801
    Related
    ENST00000528056.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

    Range
    7273972..7381547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060948.1 Alternate T2T-CHM13v2.0

    Range
    6926299..7033870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_002760.3: Suppressed sequence

    Description
    NM_002760.3: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O43930.1 GenPept UniProtKB/Swiss-Prot:O43930

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials