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TEX15 testis expressed 15, meiosis and synapsis associated [ Homo sapiens (human) ]

Gene ID: 56154, updated on 23-Mar-2017
Official Symbol
TEX15provided by HGNC
Official Full Name
testis expressed 15, meiosis and synapsis associatedprovided by HGNC
Primary source
HGNC:HGNC:11738
See related
Ensembl:ENSG00000133863 MIM:605795; Vega:OTTHUMG00000163881
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT42
Summary
This gene encodes a protein that is required for DNA double-strand break repair, chromosome synapsis, and meiotic recombination in spermatocytes. Male mice with a knockout of the orthologous gene are viable but sterile. Loss-of-function mutations in the orthologous mouse gene cause early meiotic arrest in spermatocytes, before the mid-pachytene stage. [provided by RefSeq, Mar 2017]
Orthologs
Location:
8p12
Exon count:
17
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 8 NC_000008.11 (30831544..30913012, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (30688939..30770512, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379356 Neighboring gene uncharacterized LOC105379355 Neighboring gene UBX domain protein 8 Neighboring gene protein phosphatase 2 catalytic subunit beta Neighboring gene uncharacterized LOC105379357 Neighboring gene lysophosphatidylglycerol acyltransferase 1 pseudogene 1 Neighboring gene purine rich element binding protein G Neighboring gene Werner syndrome RecQ like helicase

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Meiosis, organism-specific biosystem (from REACTOME)
    Meiosis, organism-specific biosystemDuring meiosis the replicated chromosomes of a single diploid cell are segregated into 4 haploid daughter cells by two successive divisions, meiosis I and meiosis II. In meiosis I, the distinguishing...
  • Meiotic recombination, organism-specific biosystem (from REACTOME)
    Meiotic recombination, organism-specific biosystemMeiotic recombination exchanges segments of duplex DNA between chromosomal homologs, generating genetic diversity (reviewed in Handel and Schimenti 2010, Inagaki et al. 2010, Cohen et al. 2006). Ther...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp434M2415

Gene Ontology Provided by GOA

Process Evidence Code Pubs
DNA repair IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
fertilization IEA
Inferred from Electronic Annotation
more info
 
homeostasis of number of cells within a tissue IEA
Inferred from Electronic Annotation
more info
 
male genitalia development IEA
Inferred from Electronic Annotation
more info
 
male meiosis IEA
Inferred from Electronic Annotation
more info
 
protein localization to chromosome IEA
Inferred from Electronic Annotation
more info
 
regulation of double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
 
regulation of protein localization IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
synaptonemal complex assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
testis-expressed protein 15; testis-expressed sequence 15 protein
Names
cancer/testis antigen 42

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031271.3NP_112561.2  testis-expressed protein 15

    See identical proteins and their annotated locations for NP_112561.2

    Status: VALIDATED

    Source sequence(s)
    AC090281, AF285605, AL133653
    Consensus CDS
    CCDS6080.1
    UniProtKB/Swiss-Prot
    Q9BXT5
    Related
    ENSP00000256246, OTTHUMP00000225271, ENST00000256246, OTTHUMT00000376193
    Conserved Domains (1) summary
    pfam15326
    Location:15381770
    TEX15; Testis expressed sequence 15

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p7 Primary Assembly

    Range
    30831544..30913012 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273575.3XP_005273632.1  testis-expressed sequence 15 protein isoform X2

    See identical proteins and their annotated locations for XP_005273632.1

    Conserved Domains (2) summary
    pfam12509
    Location:95250
    DUF3715; Protein of unknown function (DUF3715)
    pfam15326
    Location:19212153
    TEX15; Testis expressed sequence 15
  2. XM_011544589.2XP_011542891.1  testis-expressed sequence 15 protein isoform X2

    See identical proteins and their annotated locations for XP_011542891.1

    Conserved Domains (2) summary
    pfam12509
    Location:95250
    DUF3715; Protein of unknown function (DUF3715)
    pfam15326
    Location:19212153
    TEX15; Testis expressed sequence 15
  3. XM_011544590.2XP_011542892.1  testis-expressed sequence 15 protein isoform X2

    See identical proteins and their annotated locations for XP_011542892.1

    Conserved Domains (2) summary
    pfam12509
    Location:95250
    DUF3715; Protein of unknown function (DUF3715)
    pfam15326
    Location:19212153
    TEX15; Testis expressed sequence 15
  4. XM_006716369.3XP_006716432.1  testis-expressed sequence 15 protein isoform X2

    See identical proteins and their annotated locations for XP_006716432.1

    Conserved Domains (2) summary
    pfam12509
    Location:95250
    DUF3715; Protein of unknown function (DUF3715)
    pfam15326
    Location:19212153
    TEX15; Testis expressed sequence 15
  5. XM_011544591.2XP_011542893.1  testis-expressed sequence 15 protein isoform X2

    See identical proteins and their annotated locations for XP_011542893.1

    Conserved Domains (2) summary
    pfam12509
    Location:95250
    DUF3715; Protein of unknown function (DUF3715)
    pfam15326
    Location:19212153
    TEX15; Testis expressed sequence 15
  6. XM_011544588.2XP_011542890.1  testis-expressed sequence 15 protein isoform X1

    Conserved Domains (2) summary
    pfam12509
    Location:99254
    DUF3715; Protein of unknown function (DUF3715)
    pfam15326
    Location:19252157
    TEX15; Testis expressed sequence 15
  7. XM_011544592.2XP_011542894.1  testis-expressed sequence 15 protein isoform X2

    See identical proteins and their annotated locations for XP_011542894.1

    Conserved Domains (2) summary
    pfam12509
    Location:95250
    DUF3715; Protein of unknown function (DUF3715)
    pfam15326
    Location:19212153
    TEX15; Testis expressed sequence 15
  8. XM_005273576.3XP_005273633.1  testis-expressed sequence 15 protein isoform X3

    See identical proteins and their annotated locations for XP_005273633.1

    UniProtKB/TrEMBL
    D3DSV6
    Conserved Domains (2) summary
    pfam12509
    Location:1147
    DUF3715; Protein of unknown function (DUF3715)
    pfam15326
    Location:18182050
    TEX15; Testis expressed sequence 15
  9. XM_011544593.2XP_011542895.1  testis-expressed sequence 15 protein isoform X3

    See identical proteins and their annotated locations for XP_011542895.1

    UniProtKB/TrEMBL
    D3DSV6
    Conserved Domains (2) summary
    pfam12509
    Location:1147
    DUF3715; Protein of unknown function (DUF3715)
    pfam15326
    Location:18182050
    TEX15; Testis expressed sequence 15
  10. XM_011544594.2XP_011542896.1  testis-expressed sequence 15 protein isoform X4

    Conserved Domains (1) summary
    pfam12509
    Location:99254
    DUF3715; Protein of unknown function (DUF3715)

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 Alternate CHM1_1.1

    Range
    30890491..30907972 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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