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TEX15 testis expressed 15, meiosis and synapsis associated [ Homo sapiens (human) ]

Gene ID: 56154, updated on 24-Dec-2019

Summary

Official Symbol
TEX15provided by HGNC
Official Full Name
testis expressed 15, meiosis and synapsis associatedprovided by HGNC
Primary source
HGNC:HGNC:11738
See related
Ensembl:ENSG00000133863 MIM:605795
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT42; SPGF25
Summary
This gene encodes a protein that is required for DNA double-strand break repair, chromosome synapsis, and meiotic recombination in spermatocytes. Male mice with a knockout of the orthologous gene are viable but sterile. Loss-of-function mutations in the orthologous mouse gene cause early meiotic arrest in spermatocytes, before the mid-pachytene stage. Naturally occurring mutations in this gene are associated with nonobstructive azoospermia. [provided by RefSeq, Apr 2017]
Expression
Biased expression in testis (RPKM 7.9) and endometrium (RPKM 3.5) See more
Orthologs

Genomic context

See TEX15 in Genome Data Viewer
Location:
8p12
Exon count:
12
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (30831544..30913008, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (30688939..30770512, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379356 Neighboring gene uncharacterized LOC105379355 Neighboring gene UBX domain protein 8 Neighboring gene protein phosphatase 2 catalytic subunit beta Neighboring gene uncharacterized LOC105379357 Neighboring gene CRISPRi-validated cis-regulatory element chr8.1136 Neighboring gene lysophosphatidylglycerol acyltransferase 1 pseudogene 1 Neighboring gene purine rich element binding protein G

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434M2415

Gene Ontology Provided by GOA

Process Evidence Code Pubs
DNA repair IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
male meiotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
regulation of double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
synapsis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
testis-expressed protein 15
Names
cancer/testis antigen 42
testis-expressed sequence 15 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053141.1 RefSeqGene

    Range
    5005..86469
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001350162.2NP_001337091.1  testis-expressed protein 15

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AC090281, AF285605, AL133653, BC141841
    Consensus CDS
    CCDS87593.1
    Related
    ENSP00000493555.1, ENST00000643185.1
    Conserved Domains (2) summary
    pfam12509
    Location:103250
    DUF3715; Protein of unknown function (DUF3715)
    pfam15326
    Location:19212153
    TEX15; Testis expressed sequence 15

RNA

  1. NR_146525.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the polyadenylated site occurs disrupts the open reading frame, suggesting that the transcript may be a candidate for non-stop decay.
    Source sequence(s)
    AC090281, BC141841

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    30831544..30913008 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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