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micu1 mitochondrial calcium uptake 1 [ Danio rerio (zebrafish) ]

Gene ID: 561210, updated on 9-Sep-2025
Official Symbol
micu1provided by ZNC
Official Full Name
mitochondrial calcium uptake 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-070410-22
See related
Ensembl:ENSDARG00000063358 AllianceGenome:ZFIN:ZDB-GENE-070410-22
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cbara1; zgc:162148
Summary
Predicted to enable calcium ion binding activity and calcium ion sensor activity. Predicted to be involved in calcium ion transport; positive regulation of cristae formation; and positive regulation of mitochondrial calcium ion concentration. Predicted to act upstream of or within calcium ion transport. Predicted to be located in mitochondrial inner membrane and mitochondrial intermembrane space. Predicted to be part of uniplex complex. Is expressed in female organism; heart; and heart tube. Human ortholog(s) of this gene implicated in myopathy with extrapyramidal signs. Orthologous to human MICU1 (mitochondrial calcium uptake 1). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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See micu1 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 13 NC_133188.1 (4824127..4925177)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 13 NC_007124.7 (4871997..4969688)

Chromosome 13 - NC_133188.1Genomic Context describing neighboring genes Neighboring gene phospholipase A2, group XIIB Neighboring gene oncoprotein induced transcript 3 Neighboring gene mitochondrial calcium uniporter Neighboring gene uncharacterized LOC141377112 Neighboring gene uncharacterized LOC141377104 Neighboring gene uncharacterized LOC141377115 Neighboring gene nucleolar and coiled-body phosphoprotein 1 Neighboring gene mitochondrial ribosomal protein S6

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Mutation/SNP analysis in EF-hand calcium binding domain of mitochondrial Ca[Formula: see text] uptake 1 gene in bipolar disorder patients. Safari R, et al. J Integr Neurosci, 2016 Jun. PMID 27297032
  2. Mitochondrial Ca(2+) uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity. Shimizu H, et al. Elife, 2015 Jan 15. PMID 25588501, Free PMC Article
  3. Inhibition of the mitochondrial calcium uniporter rescues dopaminergic neurons in pink1(-/-) zebrafish. Soman S, et al. Eur J Neurosci, 2017 Feb. PMID 27859782, Free PMC Article
  4. Increasing Ca(2+) in photoreceptor mitochondria alters metabolites, accelerates photoresponse recovery, and reveals adaptations to mitochondrial stress. Hutto RA, et al. Cell Death Differ, 2020 Mar. PMID 31371786, Free PMC Article
  5. Untangling Zebrafish Genetic Annotation: Addressing Complexities and Nomenclature Issues in Orthologous Evaluation of TCOF1 and NOLC1. Hill-Terán G, et al. J Mol Evol, 2024 Dec. PMID 39269459

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Clone Names

  • MGC162148

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables calcium ion sensor activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion sensor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcium import into the mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium import into the mitochondrion IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium ion import ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial calcium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within mitochondrial calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial calcium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cristae formation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cristae formation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of mitochondrial calcium ion concentration ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of calcium channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial intermembrane space ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of uniplex complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of uniplex complex ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
calcium uptake protein 1, mitochondrial
Names
calcium-binding atopy-related autoantigen 1 homolog

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083833.2 → NP_001077302.2  calcium uptake protein 1, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    JBMGRA010000013
    Related
    ENSDARP00000121050.1, ENSDART00000132301.3

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133188.1 Reference GRCz12tu Primary Assembly

    Range
    4824127..4925177
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068212871.2 → XP_068068972.2  calcium uptake protein 1, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0AB32T6A6

  2. XM_073919636.1 → XP_073775737.1  calcium uptake protein 1, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A0A8M2B2V5, A0AB32T6A6, E9QGA3

  3. XM_005156522.6 → XP_005156579.2  calcium uptake protein 1, mitochondrial isoform X3

    UniProtKB/TrEMBL
    A0A8M2B2V5, E9QGA3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4IG32.1 GenPept UniProtKB/Swiss-Prot:A4IG32

Gene LinkOut

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