Format

Send to:

Choose Destination

THAP12 THAP domain containing 12 [ Homo sapiens (human) ]

Gene ID: 5612, updated on 4-Oct-2020

Summary

Official Symbol
THAP12provided by HGNC
Official Full Name
THAP domain containing 12provided by HGNC
Primary source
HGNC:HGNC:9440
See related
Ensembl:ENSG00000137492 MIM:607374
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAP4; THAP0; PRKRIR; P52rIPK
Expression
Ubiquitous expression in lymph node (RPKM 20.3), thyroid (RPKM 16.8) and 25 other tissues See more
Orthologs

Genomic context

See THAP12 in Genome Data Viewer
Location:
11q13.5
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (76349956..76381132, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (76061004..76091880, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene tRNA-Pro (anticodon TGG) 2-1 Neighboring gene uncharacterized LOC105369395 Neighboring gene GVQW motif containing 3 Neighboring gene Sharpr-MPRA regulatory region 9860 Neighboring gene EMSY transcriptional repressor, BRCA2 interacting

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102750

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 

General protein information

Preferred Names
52 kDa repressor of the inhibitor of the protein kinase
Names
58 kDa interferon-induced protein kinase-interacting protein
P58IPK-regulatory protein
THAP domain-containing protein 0
THAP domain-containing protein 12
death-associated protein 4
inhibitor of protein kinase PKR
p58IPK-interacting protein
protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
testicular tissue protein Li 133

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004705.4NP_004696.2  52 kDa repressor of the inhibitor of the protein kinase

    See identical proteins and their annotated locations for NP_004696.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript.
    Source sequence(s)
    AA765102, AF081567, AP002360, DR005363
    Consensus CDS
    CCDS8243.1
    UniProtKB/Swiss-Prot
    O43422
    UniProtKB/TrEMBL
    A0A140VJQ7
    Related
    ENSP00000260045.3, ENST00000260045.8
    Conserved Domains (3) summary
    pfam05485
    Location:586
    THAP; THAP domain
    pfam05699
    Location:672729
    Dimer_Tnp_hAT; hAT family C-terminal dimerisation region
    pfam14291
    Location:159330
    DUF4371; Domain of unknown function (DUF4371)

RNA

  1. NR_130898.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA765102, AF081567, AP002360, DR005363

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    76349956..76381132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center