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DNAJC3 DnaJ heat shock protein family (Hsp40) member C3 [ Homo sapiens (human) ]

Gene ID: 5611, updated on 1-Mar-2021

Summary

Official Symbol
DNAJC3provided by HGNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member C3provided by HGNC
Primary source
HGNC:HGNC:9439
See related
Ensembl:ENSG00000102580 MIM:601184
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P58; HP58; ACPHD; ERdj6; PRKRI; P58IPK; p58(IPK)
Summary
This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). [provided by RefSeq, Jul 2010]
Expression
Ubiquitous expression in thyroid (RPKM 25.8), prostate (RPKM 15.3) and 25 other tissues See more
Orthologs
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Genomic context

See DNAJC3 in Genome Data Viewer
Location:
13q32.1
Exon count:
16
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (95677139..95794988)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (96329393..96447242)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 2339 Neighboring gene DAZ interacting zinc finger protein 1 Neighboring gene DNAJC3 divergent transcript Neighboring gene MT-ND6 pseudogene 18 Neighboring gene MT-ND5 pseudogene 2 Neighboring gene MT-CYB pseudogene 3 Neighboring gene uncharacterized LOC105370322 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 24 Neighboring gene UDP-glucose glycoprotein glucosyltransferase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with DNAJC3; predicted interaction to be involved in antigenicity/immunity PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21288

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein kinase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
IRE1-mediated unfolded protein response TAS
Traceable Author Statement
more info
 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cellular response to cold ISS
Inferred from Sequence or Structural Similarity
more info
 
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of translation initiation in response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein folding in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis involved in cellular protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
azurophil granule lumen TAS
Traceable Author Statement
more info
 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular vesicle HDA PubMed 
membrane HDA PubMed 
smooth endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dnaJ homolog subfamily C member 3
Names
DnaJ (Hsp40) homolog, subfamily C, member 3
ER-resident protein ERdj6
endoplasmic reticulum DNA J domain-containing protein 6
interferon-induced, double-stranded RNA-activated protein kinase inhibitor
protein kinase inhibitor of 58 kDa
protein kinase inhibitor p58
protein-kinase, interferon-inducible double stranded RNA dependent inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_041830.1 RefSeqGene

    Range
    5001..122850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006260.5NP_006251.1  dnaJ homolog subfamily C member 3 precursor

    See identical proteins and their annotated locations for NP_006251.1

    Status: REVIEWED

    Source sequence(s)
    AA430108, AK292947, AL136104, AL138955, BC047936
    Consensus CDS
    CCDS9479.1
    UniProtKB/Swiss-Prot
    Q13217
    UniProtKB/TrEMBL
    A8KA82
    Related
    ENSP00000473631.1, ENST00000602402.6
    Conserved Domains (3) summary
    COG0484
    Location:392498
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    sd00006
    Location:3765
    TPR; TPR repeat [structural motif]
    cl26002
    Location:31394
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    95677139..95794988
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521104.3XP_011519406.1  dnaJ homolog subfamily C member 3 isoform X1

    Conserved Domains (6) summary
    COG0484
    Location:421527
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    sd00006
    Location:3765
    TPR; TPR repeat [structural motif]
    pfam00226
    Location:423488
    DnaJ; DnaJ domain
    pfam00515
    Location:369402
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:36100
    TPR_11; TPR repeat
    pfam14559
    Location:347411
    TPR_19; Tetratricopeptide repeat
  2. XM_011521105.2XP_011519407.1  dnaJ homolog subfamily C member 3 isoform X2

    Conserved Domains (6) summary
    COG0484
    Location:338444
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    sd00006
    Location:103128
    TPR; TPR repeat [structural motif]
    pfam00226
    Location:340405
    DnaJ; DnaJ domain
    pfam00515
    Location:286319
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:133198
    TPR_11; TPR repeat
    pfam14559
    Location:264328
    TPR_19; Tetratricopeptide repeat
  3. XM_017020674.2XP_016876163.1  dnaJ homolog subfamily C member 3 isoform X3

  4. XM_017020675.2XP_016876164.1  dnaJ homolog subfamily C member 3 isoform X4

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