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DNAJC3 DnaJ heat shock protein family (Hsp40) member C3 [ Homo sapiens (human) ]

Gene ID: 5611, updated on 5-Aug-2018

Summary

Official Symbol
DNAJC3provided by HGNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member C3provided by HGNC
Primary source
HGNC:HGNC:9439
See related
Ensembl:ENSG00000102580 MIM:601184; Vega:OTTHUMG00000017227
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P58; HP58; ACPHD; ERdj6; PRKRI; P58IPK
Summary
This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). [provided by RefSeq, Jul 2010]
Expression
Ubiquitous expression in thyroid (RPKM 25.8), prostate (RPKM 15.3) and 25 other tissues See more
Orthologs

Genomic context

See DNAJC3 in Genome Data Viewer
Location:
13q32.1
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 13 NC_000013.11 (95677139..95794989)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (96329393..96447243)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene claudin 10 Neighboring gene DAZ interacting zinc finger protein 1 Neighboring gene DNAJC3 divergent transcript Neighboring gene MT-ND6 pseudogene 18 Neighboring gene MT-ND5 pseudogene 2 Neighboring gene MT-CYB pseudogene 3 Neighboring gene uncharacterized LOC105370322 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 24 Neighboring gene UDP-glucose glycoprotein glucosyltransferase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with DNAJC3; predicted interaction to be involved in antigenicity/immunity PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • IRE1alpha activates chaperones, organism-specific biosystem (from REACTOME)
    IRE1alpha activates chaperones, organism-specific biosystemIRE1-alpha is a single-pass transmembrane protein that resides in the endoplasmic reticulum (ER) membrane. The C-terminus of IRE1-alpha is located in the cytosol; the N-terminus is located in the ER ...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Infectious disease, organism-specific biosystem (from REACTOME)
    Infectious disease, organism-specific biosystem
    Infectious disease
  • Influenza A, organism-specific biosystem (from KEGG)
    Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Influenza A, conserved biosystem (from KEGG)
    Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Influenza Infection, organism-specific biosystem (from REACTOME)
    Influenza Infection, organism-specific biosystemFor centuries influenza epidemics have plagued man, and influenza was probably the disease described by Hippocrates in 412 BC. Today it remains a major cause of morbidity and mortality worldwide with...
  • Influenza Life Cycle, organism-specific biosystem (from REACTOME)
    Influenza Life Cycle, organism-specific biosystemThe virus particle initially associates with a human host cell by binding to sialic acid-containing receptors on the host cell surface. The bound virus is endocytosed by one of four distinct mechanis...
  • Influenza Viral RNA Transcription and Replication, organism-specific biosystem (from REACTOME)
    Influenza Viral RNA Transcription and Replication, organism-specific biosystemIn the host cell nucleus, the viral negative-strand RNA (vRNA) serves as a template for the synthesis both of capped, polyadenylated viral messenger RNA and of full-length positive-strand RNA or comp...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
  • Photodynamic therapy-induced unfolded protein response, organism-specific biosystem (from WikiPathways)
    Photodynamic therapy-induced unfolded protein response, organism-specific biosystemPhotodynamic therapy may induce a proteotoxic stress response mediated by transcription factors heat shock factor 1 (HSF1), X-box binding protein 1 (XBP1), activating transcription factor (ATF) 6, an...
  • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Unfolded Protein Response (UPR), organism-specific biosystem (from REACTOME)
    Unfolded Protein Response (UPR), organism-specific biosystemThe Unfolded Protein Response (UPR) is a regulatory system that protects the Endoplasmic Reticulum (ER) from overload. The UPR is provoked by the accumulation of improperly folded protein in the ER d...
  • Viral mRNA Translation, organism-specific biosystem (from REACTOME)
    Viral mRNA Translation, organism-specific biosystemSpliced and unspliced viral mRNA in the cytoplasm are translated by host cell ribosomal translation machinery (reviewed in Kash, 2006). At least ten viral proteins are synthesized: HA, NA, PB1, PB2...
  • XBP1(S) activates chaperone genes, organism-specific biosystem (from REACTOME)
    XBP1(S) activates chaperone genes, organism-specific biosystemXbp-1 (S) binds the sequence CCACG in ER Stress Responsive Elements (ERSE, consensus sequence CCAAT (N)9 CCACG) located upstream from many genes. The ubiquitous transcription factor NF-Y, a heterotri...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21288

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperone binding IEA
Inferred from Electronic Annotation
more info
 
misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
misfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein kinase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
IRE1-mediated unfolded protein response TAS
Traceable Author Statement
more info
 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cellular response to cold ISS
Inferred from Sequence or Structural Similarity
more info
 
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of translation initiation in response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein folding in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis involved in cellular protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
azurophil granule lumen TAS
Traceable Author Statement
more info
 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum Sec complex IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular vesicle HDA PubMed 
membrane HDA PubMed 
smooth endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dnaJ homolog subfamily C member 3
Names
DnaJ (Hsp40) homolog, subfamily C, member 3
ER-resident protein ERdj6
endoplasmic reticulum DNA J domain-containing protein 6
interferon-induced, double-stranded RNA-activated protein kinase inhibitor
protein kinase inhibitor of 58 kDa
protein kinase inhibitor p58
protein-kinase, interferon-inducible double stranded RNA dependent inhibitor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_041830.1 RefSeqGene

    Range
    5001..122851
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006260.4NP_006251.1  dnaJ homolog subfamily C member 3 precursor

    See identical proteins and their annotated locations for NP_006251.1

    Status: REVIEWED

    Source sequence(s)
    AA430108, AK292947, AL136104, AL138955, BC047936
    Consensus CDS
    CCDS9479.1
    UniProtKB/Swiss-Prot
    Q13217
    UniProtKB/TrEMBL
    A8KA82
    Related
    ENSP00000473631.1, OTTHUMP00000018567, ENST00000602402.5, OTTHUMT00000045504
    Conserved Domains (3) summary
    COG0484
    Location:392498
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    sd00006
    Location:3765
    TPR; TPR repeat [structural motif]
    cl26002
    Location:31394
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p12 Primary Assembly

    Range
    95677139..95794989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521104.3XP_011519406.1  dnaJ homolog subfamily C member 3 isoform X1

    Conserved Domains (6) summary
    COG0484
    Location:421527
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    sd00006
    Location:3765
    TPR; TPR repeat [structural motif]
    pfam00226
    Location:423488
    DnaJ; DnaJ domain
    pfam00515
    Location:369402
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:36100
    TPR_11; TPR repeat
    pfam14559
    Location:347411
    TPR_19; Tetratricopeptide repeat
  2. XM_011521105.2XP_011519407.1  dnaJ homolog subfamily C member 3 isoform X2

    Conserved Domains (6) summary
    COG0484
    Location:338444
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    sd00006
    Location:103128
    TPR; TPR repeat [structural motif]
    pfam00226
    Location:340405
    DnaJ; DnaJ domain
    pfam00515
    Location:286319
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:133198
    TPR_11; TPR repeat
    pfam14559
    Location:264328
    TPR_19; Tetratricopeptide repeat
  3. XM_017020674.2XP_016876163.1  dnaJ homolog subfamily C member 3 isoform X3

  4. XM_017020675.2XP_016876164.1  dnaJ homolog subfamily C member 3 isoform X4

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