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lamtor4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 [ Danio rerio (zebrafish) ]

Gene ID: 561019, updated on 3-Dec-2024

Summary

Official Symbol
lamtor4provided by ZNC
Official Full Name
late endosomal/lysosomal adaptor, MAPK and MTOR activator 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-7438
See related
Ensembl:ENSDARG00000045542 AllianceGenome:ZFIN:ZDB-GENE-030131-7438
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fj17e01; wu:fj17e01; zgc:153714; si:dkey-159a18.7
Summary
Predicted to contribute to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Predicted to be involved in several processes, including cellular response to amino acid stimulus; positive regulation of TORC1 signaling; and protein localization to lysosome. Predicted to be part of Ragulator complex. Predicted to be active in lysosomal membrane. Orthologous to human LAMTOR4 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See lamtor4 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (20051460..20054580)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (20062484..20065604)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene zgc:193726 Neighboring gene ATPase H+ transporting V1 subunit F Neighboring gene zmp:0000000938 Neighboring gene GRIP and coiled-coil domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC153714

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
contributes_to guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
contributes_to molecular adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in cellular response to amino acid stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cellular response to amino acid stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to amino acid stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of TOR signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of TOR signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of TORC1 signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization to lysosome ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell size ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of Ragulator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Ragulator complex IEA
Inferred from Electronic Annotation
more info
 
part_of Ragulator complex ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in lysosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
ragulator complex protein LAMTOR4
Names
UPF0539 protein C7orf59 homolog
late endosomal/lysosomal adaptor and MAPK and MTOR activator 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044950.1NP_001038415.1  ragulator complex protein LAMTOR4

    See identical proteins and their annotated locations for NP_001038415.1

    Status: PROVISIONAL

    Source sequence(s)
    BC122392
    UniProtKB/Swiss-Prot
    Q0P3X8, Q5RGI9
    UniProtKB/TrEMBL
    A0A8M9Q5X7
    Related
    ENSDARP00000115287.2, ENSDART00000143642.2

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    20051460..20054580
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)