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MAP2K7 mitogen-activated protein kinase kinase 7 [ Homo sapiens (human) ]

Gene ID: 5609, updated on 5-Sep-2021

Summary

Official Symbol
MAP2K7provided by HGNC
Official Full Name
mitogen-activated protein kinase kinase 7provided by HGNC
Primary source
HGNC:HGNC:6847
See related
Ensembl:ENSG00000076984 MIM:603014
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MEK; MKK7; JNKK2; MEK 7; MAPKK7; PRKMK7; SAPKK4; SAPKK-4
Summary
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Expression
Ubiquitous expression in testis (RPKM 9.3), spleen (RPKM 8.9) and 25 other tissues See more
Orthologs
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Genomic context

See MAP2K7 in Genome Data Viewer
Location:
19p13.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (7903785..7914478)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (7968762..7979363)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 463 Neighboring gene leucine rich repeat containing 8 VRAC subunit E Neighboring gene transforming growth factor beta receptor 3 like Neighboring gene small nuclear RNA activating complex polypeptide 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr Activation of TAK1 by HIV-1 Vpr leads to increased levels of phosphorylated IKK-beta and MKK7 in cells PubMed
vpr Synthetic HIV-1 Vpr protein activates AP-1 (Jun/Fos), c-Jun N-terminal kinase (JNK), NF-kappaB, and MKK7 in both U937 cells and primary macrophages. PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables JUN kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables JUN kinase kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables JUN kinase kinase activity TAS
Traceable Author Statement
more info
 
enables MAP kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables MAP kinase kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in JNK cascade TAS
Traceable Author Statement
more info
 
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular senescence TAS
Traceable Author Statement
more info
 
involved_in peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of JUN kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of telomerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of telomere capping IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of telomere maintenance via telomerase IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to UV IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to heat IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to osmotic stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in stress-activated MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in stress-activated MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
dual specificity mitogen-activated protein kinase kinase 7
Names
JNK-activating kinase 2
MAP kinase kinase 7
MAPK/ERK kinase 7
SAPK kinase 4
c-Jun N-terminal kinase kinase 2
stress-activated protein kinase kinase 4
NP_001284484.1
NP_001284485.1
NP_660186.1
XP_006722863.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029438.2 RefSeqGene

    Range
    4998..15599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001297555.2NP_001284484.1  dual specificity mitogen-activated protein kinase kinase 7 isoform 1

    See identical proteins and their annotated locations for NP_001284484.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK098807, AK300988, BC038295, BF445461, DQ445915, HY063492
    Consensus CDS
    CCDS74277.1
    UniProtKB/Swiss-Prot
    O14733
    UniProtKB/TrEMBL
    B4DV95
    Related
    ENSP00000381070.2, ENST00000397983.7
    Conserved Domains (1) summary
    cd06618
    Location:120416
    PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7
  2. NM_001297556.2NP_001284485.1  dual specificity mitogen-activated protein kinase kinase 7 isoform 2

    See identical proteins and their annotated locations for NP_001284485.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK098807, AK300988, BC038295, BF445461, HY063492
    Consensus CDS
    CCDS74278.1
    UniProtKB/Swiss-Prot
    O14733
    UniProtKB/TrEMBL
    B4DV95
    Related
    ENSP00000381068.3, ENST00000397981.7
    Conserved Domains (1) summary
    cd06618
    Location:104407
    PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7
  3. NM_145185.4NP_660186.1  dual specificity mitogen-activated protein kinase kinase 7 isoform 3

    See identical proteins and their annotated locations for NP_660186.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 3, which lacks an internal segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AF022805, AK098807, BC038295, BF445461, HY063492
    Consensus CDS
    CCDS42491.1
    UniProtKB/Swiss-Prot
    O14733
    Related
    ENSP00000381066.3, ENST00000397979.4
    Conserved Domains (1) summary
    cd06618
    Location:104400
    PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    7903785..7914478
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722800.2XP_006722863.1  dual specificity mitogen-activated protein kinase kinase 7 isoform X1

    See identical proteins and their annotated locations for XP_006722863.1

    Conserved Domains (1) summary
    cd06618
    Location:120423
    PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7
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