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mier3a mesoderm induction early response 1, family member 3 a [ Danio rerio (zebrafish) ]

Gene ID: 560884, updated on 9-Sep-2025
Official Symbol
mier3aprovided by ZNC
Official Full Name
mesoderm induction early response 1, family member 3 aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050913-97
See related
Ensembl:ENSDARG00000006253 AllianceGenome:ZFIN:ZDB-GENE-050913-97
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
mier3; zgc:114199
Summary
Predicted to enable histone deacetylase binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in breast cancer and lung adenocarcinoma. Orthologous to human MIER3 (MIER family member 3). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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See mier3a in Genome Data Viewer
Location:
chromosome: 10
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 10 NC_133185.1 (3168735..3185219, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 10 NC_007121.7 (2696864..2713228, complement)

Chromosome 10 - NC_133185.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC141376286 Neighboring gene SET domain containing 9 Neighboring gene pyridoxal (pyridoxine, vitamin B6) phosphatase Neighboring gene G protein-coupled receptor kinase 5 Neighboring gene ash2 like, histone lysine methyltransferase complex subunit

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Clone Names

  • MGC114199

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
mesoderm induction early response protein 3a

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030149.2 → NP_001025320.2  mesoderm induction early response protein 3a

    Status: VALIDATED

    Source sequence(s)
    BC133852, CT718078, EB950527
    UniProtKB/TrEMBL
    A0A8M1N785, A4FVG8, F1Q9V8
    Related
    ENSDARP00000106810.2, ENSDART00000123754.3
    Conserved Domains (3) summary
    smart00717
    Location:273 → 319
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:274 → 318
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:172 → 222
    ELM2; ELM2 domain

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133185.1 Reference GRCz12tu Primary Assembly

    Range
    3168735..3185219 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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