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Psmg1 proteasome (prosome, macropain) assembly chaperone 1 [ Mus musculus (house mouse) ]

Gene ID: 56088, updated on 30-Apr-2024

Summary

Official Symbol
Psmg1provided by MGI
Official Full Name
proteasome (prosome, macropain) assembly chaperone 1provided by MGI
Primary source
MGI:MGI:1860263
See related
Ensembl:ENSMUSG00000022913 AllianceGenome:MGI:1860263
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dscr2
Summary
Enables proteasome binding activity. Acts upstream of or within cerebellar granule cell precursor proliferation and proteasome core complex assembly. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be part of chaperone complex. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human PSMG1 (proteasome assembly chaperone 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 32.4), placenta adult (RPKM 19.0) and 27 other tissues See more
Orthologs
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Genomic context

See Psmg1 in Genome Data Viewer
Location:
16 C4; 16 56.76 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (95781133..95792160, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (95979933..95990960, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1600002D24 gene Neighboring gene predicted gene 15340 Neighboring gene predicted gene, 41508 Neighboring gene STARR-positive B cell enhancer ABC_E1930 Neighboring gene STARR-seq mESC enhancer starr_41608 Neighboring gene STARR-seq mESC enhancer starr_41610 Neighboring gene STARR-positive B cell enhancer mm9_chr16:96212367-96212668 Neighboring gene STARR-seq mESC enhancer starr_41611 Neighboring gene bromodomain and WD repeat domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_41612 Neighboring gene STARR-seq mESC enhancer starr_41614 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:96307304-96307505 Neighboring gene STARR-positive B cell enhancer mm9_chr16:96331382-96331682 Neighboring gene STARR-positive B cell enhancer mm9_chr16:96349246-96349547 Neighboring gene high mobility group nucleosomal binding domain 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables proteasome binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables proteasome binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of protein folding chaperone complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
proteasome assembly chaperone 1
Names
Down syndrome critical region homolog 2
down syndrome critical region protein 2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019537.3NP_062410.1  proteasome assembly chaperone 1

    See identical proteins and their annotated locations for NP_062410.1

    Status: VALIDATED

    Source sequence(s)
    BC032965, BG086724
    Consensus CDS
    CCDS28352.1
    UniProtKB/Swiss-Prot
    Q8BU12, Q9JK23
    UniProtKB/TrEMBL
    A0A3B2WB82
    Related
    ENSMUSP00000023630.8, ENSMUST00000023630.16
    Conserved Domains (1) summary
    pfam16094
    Location:2288
    PAC1; Proteasome assembly chaperone 4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    95781133..95792160 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)