tpi1b triosephosphate isomerase 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tpi1bprovided by ZNC
Official Full Name: triosephosphate isomerase 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020416-4
See related: Ensembl:ENSDARG00000040988 AllianceGenome:ZFIN:ZDB-GENE-020416-4
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: TIM-B; cb179; DrTPI-B; wu:fb51c02
Summary: Predicted to enable methylglyoxal synthase activity; protein homodimerization activity; and triose-phosphate isomerase activity. Predicted to be involved in several processes, including carbohydrate catabolic process; gluconeogenesis; and glyceraldehyde-3-phosphate biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including brain; cardiovascular system; mesoderm; musculature system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and triosephosphate isomerase deficiency. Orthologous to human TPI1 (triosephosphate isomerase 1). [provided by Alliance of Genome Resources, May 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	16	NC_133191.1 (12588724..12603004)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (12240605..12255175)

Chromosome 16 - NC_133191.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

fb51c02.x1 (e-PCR)
- UniSTS:203264

AI477266 (e-PCR)
- UniSTS:206499

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables methylglyoxal synthase activity	IEA Inferred from Electronic Annotation more info
enables methylglyoxal synthase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables triose-phosphate isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables triose-phosphate isomerase activity	IEA Inferred from Electronic Annotation more info
enables triose-phosphate isomerase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in glyceraldehyde-3-phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glyceraldehyde-3-phosphate biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycerol catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in methylglyoxal biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: triosephosphate isomerase B

Names: methylglyoxal synthase B; triose-phosphate isomerase B

NP_705954.2

EC 4.2.3.3

EC 5.3.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.