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Lgals12 lectin, galactose binding, soluble 12 [ Mus musculus (house mouse) ]

Gene ID: 56072, updated on 5-Jan-2023

Summary

Official Symbol
Lgals12provided by MGI
Official Full Name
lectin, galactose binding, soluble 12provided by MGI
Primary source
MGI:MGI:1929094
See related
Ensembl:ENSMUSG00000024972 AllianceGenome:MGI:1929094
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Grip1; gal-12
Summary
Predicted to enable integrin binding activity and lactose binding activity. Predicted to be involved in intrinsic apoptotic signaling pathway and lymphatic endothelial cell migration. Predicted to act upstream of or within apoptotic process. Located in mitochondrion and nucleus. Orthologous to human LGALS12 (galectin 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 28.5), mammary gland adult (RPKM 22.2) and 8 other tissues See more
Orthologs
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Genomic context

See Lgals12 in Genome Data Viewer
Location:
19; 19 A
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (7574021..7584601, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (7596656..7607233, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene atlastin GTPase 3 Neighboring gene phospholipase A and acyltransferase 3 Neighboring gene phospholipase A and acyltransferase 5 Neighboring gene IscU iron-sulfur cluster scaffold homolog pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables lactose binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lactose binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
galectin-12
Names
galectin-related inhibitor of proliferation 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356574.2NP_001343503.1  galectin-12 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC109225
    Consensus CDS
    CCDS29529.1
    UniProtKB/Swiss-Prot
    Q9JKX2
    Related
    ENSMUSP00000124610.2, ENSMUST00000159983.8
    Conserved Domains (2) summary
    smart00908
    Location:195313
    Gal-bind_lectin; Galactoside-binding lectin
    pfam00337
    Location:26158
    Gal-bind_lectin; Galactoside-binding lectin
  2. NM_001370686.1NP_001357615.1  galectin-12 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC109225
    Consensus CDS
    CCDS89332.1
    Related
    ENSMUSP00000078824.6, ENSMUST00000079902.6
    Conserved Domains (2) summary
    smart00908
    Location:182300
    Gal-bind_lectin; Galactoside-binding lectin
    pfam00337
    Location:26158
    Gal-bind_lectin; Galactoside-binding lectin
  3. NM_019516.5NP_062389.1  galectin-12 isoform 1

    See identical proteins and their annotated locations for NP_062389.1

    Status: VALIDATED

    Source sequence(s)
    AC109225
    Consensus CDS
    CCDS29529.1
    UniProtKB/Swiss-Prot
    Q91VD1, Q9JKX2
    Related
    ENSMUSP00000097318.4, ENSMUST00000099729.10
    Conserved Domains (2) summary
    smart00908
    Location:195313
    Gal-bind_lectin; Galactoside-binding lectin
    pfam00337
    Location:26158
    Gal-bind_lectin; Galactoside-binding lectin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    7574021..7584601 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527221.5XP_006527284.1  galectin-12 isoform X1

    Conserved Domains (2) summary
    pfam00337
    Location:26158
    Gal-bind_lectin; Galactoside-binding lectin
    cl00071
    Location:195266
    GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...