Lgals12 lectin, galactose binding, soluble 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lgals12provided by MGI
Official Full Name: lectin, galactose binding, soluble 12provided by MGI
Primary source: MGI:MGI:1929094
See related: Ensembl:ENSMUSG00000024972 AllianceGenome:MGI:1929094
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Grip1; gal-12
Summary: Predicted to enable integrin binding activity and lactose binding activity. Predicted to be involved in intrinsic apoptotic signaling pathway and lymphatic endothelial cell migration. Predicted to act upstream of or within apoptotic process. Located in mitochondrion and nucleus. Orthologous to human LGALS12 (galectin 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 28.5), mammary gland adult (RPKM 22.2) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19; 19 A

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (7574021..7584601, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (7596656..7607233, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ablation of Galectin-12 Inhibits Atherosclerosis through Enhancement of M2 Macrophage Polarization.
Title: Ablation of Galectin-12 Inhibits Atherosclerosis through Enhancement of M2 Macrophage Polarization.
The activation of STAT3 was much higher in Gal12(-/-) macrophages activated by lipopolysaccharide, which was correlated with higher levels of IL-10. Adipocytes showed higher insulin sensitivity when treated with Gal12(-/-) macrophage-conditioned media than those treated with Gal12(+/+) macrophages.
Title: Galectin-12 enhances inflammation by promoting M1 polarization of macrophages and reduces insulin sensitivity in adipocytes.
galectin 12 has a role in mitochondrial respiration, adiposity, and insulin resistance/glucose intolerance
Title: Ablation of a galectin preferentially expressed in adipocytes increases lipolysis, reduces adiposity, and improves insulin sensitivity in mice.
Results suggest that galectin-12 is required for signal transduction that conveys hormone stimulation to the induction of adipogenic factors essential for adipocyte differentiation.
Title: Galectin-12 is required for adipogenic signaling and adipocyte differentiation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

General gene information

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Homology

Homologs of the Lgals12 gene: The Lgals12 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, and frog.
Orthologs from Annotation Pipeline: 212 organisms have orthologs with human gene Lgals12
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables lactose binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables lactose binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of lipid catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: galectin-12

Names: galectin-related inhibitor of proliferation 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356574.2 → NP_001343503.1 galectin-12 isoform 1

Status: VALIDATED

Source sequence(s)

AC109225

Consensus CDS

CCDS29529.1

UniProtKB/Swiss-Prot

Q9JKX2

Related

ENSMUSP00000124610.2, ENSMUST00000159983.8

Conserved Domains (2) summary

smart00908
Location:195 → 313

Gal-bind_lectin; Galactoside-binding lectin

pfam00337
Location:26 → 158

Gal-bind_lectin; Galactoside-binding lectin
NM_001370686.1 → NP_001357615.1 galectin-12 isoform 2

Status: VALIDATED

Source sequence(s)

AC109225

Consensus CDS

CCDS89332.1

Related

ENSMUSP00000078824.6, ENSMUST00000079902.6

Conserved Domains (2) summary

smart00908
Location:182 → 300

Gal-bind_lectin; Galactoside-binding lectin

pfam00337
Location:26 → 158

Gal-bind_lectin; Galactoside-binding lectin
NM_019516.5 → NP_062389.1 galectin-12 isoform 1

See identical proteins and their annotated locations for NP_062389.1

Status: VALIDATED

Source sequence(s)

AC109225

Consensus CDS

CCDS29529.1

UniProtKB/Swiss-Prot

Q91VD1, Q9JKX2

Related

ENSMUSP00000097318.4, ENSMUST00000099729.10

Conserved Domains (2) summary

smart00908
Location:195 → 313

Gal-bind_lectin; Galactoside-binding lectin

pfam00337
Location:26 → 158

Gal-bind_lectin; Galactoside-binding lectin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

7574021..7584601 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006527221.5 → XP_006527284.1 galectin-12 isoform X1

Conserved Domains (2) summary

pfam00337
Location:26 → 158

Gal-bind_lectin; Galactoside-binding lectin

cl00071
Location:195 → 266

GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...