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mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase [ Danio rerio (zebrafish) ]

Gene ID: 560667, updated on 19-May-2025
Official Symbol
mtrrprovided by ZNC
Official Full Name
5-methyltetrahydrofolate-homocysteine methyltransferase reductaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-101115-3
See related
Ensembl:ENSDARG00000045398 AllianceGenome:ZFIN:ZDB-GENE-101115-3
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable FMN binding activity; [methionine synthase] reductase (NADPH) activity; and flavin adenine dinucleotide binding activity. Predicted to be involved in homocysteine metabolic process and methionine biosynthetic process. Predicted to act upstream of or within amino acid biosynthetic process. Predicted to be active in cytosol. Used to study visceral heterotaxy. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; endocrine gland cancer (multiple); heart disease (multiple); hematologic cancer (multiple); and homocystinuria. Orthologous to human MTRR (5-methyltetrahydrofolate-homocysteine methyltransferase reductase). [provided by Alliance of Genome Resources, May 2025]
Orthologs
human mouse all
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Location:
chromosome: 24
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 24 NC_133199.1 (20724695..20774550, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 24 NC_007135.7 (16855161..16905018, complement)

Chromosome 24 - NC_133199.1Genomic Context describing neighboring genes Neighboring gene sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A Neighboring gene uncharacterized LOC141380659 Neighboring gene uncharacterized LOC141380661 Neighboring gene uncharacterized LOC137489227 Neighboring gene transfer RNA threonine (anticodon AGU) Neighboring gene chaperonin containing TCP1, subunit 5 (epsilon) Neighboring gene carboxymethylenebutenolidase homolog (Pseudomonas)

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Imbalanced mitochondrial function provokes heterotaxy via aberrant ciliogenesis. Burkhalter MD, et al. J Clin Invest, 2019 May 16. PMID 31094706, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables FMN binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables FMN binding IEA
Inferred from Electronic Annotation
more info
  
enables [methionine synthase] reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables [methionine synthase] reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in homocysteine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in methionine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
methionine synthase reductase
NP_001373459.1
XP_005162677.1
XP_005162678.1
XP_073796555.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001386530.1 → NP_001373459.1  methionine synthase reductase

    Status: VALIDATED

    Source sequence(s)
    BX004771, BX469922
    UniProtKB/TrEMBL
    A0A8N7TD34, F1RE28
    Related
    ENSDARP00000066758.4, ENSDART00000066759.6
    Conserved Domains (2) summary
    cd06203
    Location:274 → 696
    methionine_synthase_red; Human methionine synthase reductase (MSR) restores methionine sythase which is responsible for the regeneration of methionine from homocysteine, as well as the coversion of methyltetrahydrofolate to tetrahydrofolate. In MSR, electrons are transferred ...
    pfam00258
    Location:11 → 147
    Flavodoxin_1

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133199.1 Reference GRCz12tu Primary Assembly

    Range
    20724695..20774550 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073940454.1 → XP_073796555.1  methionine synthase reductase isoform X3

  2. XM_005162621.5 → XP_005162678.1  methionine synthase reductase isoform X2

    UniProtKB/TrEMBL
    A0A0R4IZR6, A0A8M2B9T6
    Related
    ENSDARP00000141793.2, ENSDART00000165972.3
    Conserved Domains (3) summary
    cd06203
    Location:272 → 694
    methionine_synthase_red; Human methionine synthase reductase (MSR) restores methionine sythase which is responsible for the regeneration of methionine from homocysteine, as well as the coversion of methyltetrahydrofolate to tetrahydrofolate. In MSR, electrons are transferred ...
    TIGR01931
    Location:3 → 694
    cysJ; sulfite reductase [NADPH] flavoprotein, alpha-component
    pfam00258
    Location:16 → 145
    Flavodoxin_1; Flavodoxin

  3. XM_005162620.4 → XP_005162677.1  methionine synthase reductase isoform X1

    UniProtKB/TrEMBL
    A0A8M2B9H1
    Conserved Domains (3) summary
    cd06203
    Location:274 → 695
    methionine_synthase_red; Human methionine synthase reductase (MSR) restores methionine sythase which is responsible for the regeneration of methionine from homocysteine, as well as the coversion of methyltetrahydrofolate to tetrahydrofolate. In MSR, electrons are transferred ...
    COG0369
    Location:4 → 695
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
    pfam00258
    Location:11 → 147
    Flavodoxin_1; Flavodoxin
Nucleotide Protein Strain
Heading Accession and Version

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