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MAP2K3 mitogen-activated protein kinase kinase 3 [ Homo sapiens (human) ]

Gene ID: 5606, updated on 31-Dec-2019

Summary

Official Symbol
MAP2K3provided by HGNC
Official Full Name
mitogen-activated protein kinase kinase 3provided by HGNC
Primary source
HGNC:HGNC:6843
See related
Ensembl:ENSG00000034152 MIM:602315
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MEK3; MKK3; MAPKK3; PRKMK3; SAPKK2; SAPKK-2
Summary
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 62.9), gall bladder (RPKM 18.4) and 23 other tissues See more
Orthologs

Genomic context

See MAP2K3 in Genome Data Viewer
Location:
17p11.2
Exon count:
16
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (21284679..21315240)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (21187968..21218552)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene N-acetyltransferase domain containing 1 Neighboring gene eukaryotic translation initiation factor 1 pseudogene 5 Neighboring gene potassium inwardly rectifying channel subfamily J member 12 Neighboring gene PDZ and LIM domain 1 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat The interaction of HIV-1 Tat with cellular transcription factors CDK9 and Sp1 is required for Tat activation of MAP2K3-, MAP2K6-, and IRF7-mediated luciferase transcription PubMed
tat SiRNA-mediated inhibition of MAP2K6 and MAP2K3 reduces HIV-1 Tat-induced modulation of interferon (IFN)-stimulated genes PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
activation of MAPK activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of MAPK activity TAS
Traceable Author Statement
more info
 
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cardiac muscle contraction IEA
Inferred from Electronic Annotation
more info
 
cellular response to vascular endothelial growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
p38MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood vessel endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cytokine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
signal transduction by protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
membrane HDA PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
dual specificity mitogen-activated protein kinase kinase 3
Names
MAP kinase kinase 3
MAPK/ERK kinase 3
MAPKK 3
MEK 3
SAPK kinase 2
stress-activated protein kinase kinase 2
NP_001303261.1
NP_002747.2
NP_659731.1
XP_005256780.1
XP_011522260.1
XP_011522261.1
XP_016880346.1
XP_016880347.1
XP_016880348.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028256.2 RefSeqGene

    Range
    5056..35577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001316332.2NP_001303261.1  dual specificity mitogen-activated protein kinase kinase 3 isoform A

    Status: REVIEWED

    Description
    Transcript Variant: This variant (D) contains an alternate 5' exon compared to variant B. This difference results in a distinct 5' UTR and causes translation initiation at a downstream start codon compared to variant B. The resulting isoform (A) is shorter at the N-terminus compared to isoform B. Variants A and D both encode the same isoform (A).
    Source sequence(s)
    AC087294, AI758302, AK093838, DA131175
    Consensus CDS
    CCDS11218.1
    UniProtKB/Swiss-Prot
    P46734
    Conserved Domains (1) summary
    cd06617
    Location:33315
    PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
  2. NM_002756.4NP_002747.2  dual specificity mitogen-activated protein kinase kinase 3 isoform A

    See identical proteins and their annotated locations for NP_002747.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A) represents use of an alternate promoter and 5' UTR and uses a downstream start codon compared to variant B. The resulting isoform (A) is shorter at the N-terminus compared to isoform B. Variants A and D both encode the same isoform (A).
    Source sequence(s)
    AI758302, BC032478, DA987047
    Consensus CDS
    CCDS11218.1
    UniProtKB/Swiss-Prot
    P46734
    Related
    ENSP00000355081.5, ENST00000361818.9
    Conserved Domains (1) summary
    cd06617
    Location:33315
    PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
  3. NM_145109.3NP_659731.1  dual specificity mitogen-activated protein kinase kinase 3 isoform B

    See identical proteins and their annotated locations for NP_659731.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (B) encodes the longer isoform (B).
    Source sequence(s)
    AI758302, BC032478, D87116, DA131175
    Consensus CDS
    CCDS11217.1
    UniProtKB/Swiss-Prot
    P46734
    UniProtKB/TrEMBL
    Q6FI23
    Related
    ENSP00000345083.4, ENST00000342679.9
    Conserved Domains (1) summary
    cd06617
    Location:62344
    PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    21284679..21315240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024859.1XP_016880348.1  dual specificity mitogen-activated protein kinase kinase 3 isoform X3

    UniProtKB/Swiss-Prot
    P46734
    Conserved Domains (1) summary
    cd06617
    Location:33315
    PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
  2. XM_005256723.2XP_005256780.1  dual specificity mitogen-activated protein kinase kinase 3 isoform X3

    See identical proteins and their annotated locations for XP_005256780.1

    UniProtKB/Swiss-Prot
    P46734
    Conserved Domains (1) summary
    cd06617
    Location:33315
    PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
  3. XM_017024857.2XP_016880346.1  dual specificity mitogen-activated protein kinase kinase 3 isoform X2

  4. XM_011523959.2XP_011522261.1  dual specificity mitogen-activated protein kinase kinase 3 isoform X3

    See identical proteins and their annotated locations for XP_011522261.1

    UniProtKB/Swiss-Prot
    P46734
    Related
    ENSP00000478619.1, ENST00000613338.4
    Conserved Domains (1) summary
    cd06617
    Location:33315
    PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
  5. XM_017024858.1XP_016880347.1  dual specificity mitogen-activated protein kinase kinase 3 isoform X3

    UniProtKB/Swiss-Prot
    P46734
    Related
    ENSP00000319139.6, ENST00000316920.10
    Conserved Domains (1) summary
    cd06617
    Location:33315
    PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
  6. XM_011523958.2XP_011522260.1  dual specificity mitogen-activated protein kinase kinase 3 isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:38240
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:33231
    PKc_like; Protein Kinases, catalytic domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_145110.1: Suppressed sequence

    Description
    NM_145110.1: This RefSeq was temporarily suppressed because currently there are not sufficient data to support this transcript.
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