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tgfbr1a transforming growth factor, beta receptor 1 a [ Danio rerio (zebrafish) ]

Gene ID: 560578, updated on 23-Aug-2018

Summary

Official Symbol
tgfbr1aprovided by ZNC
Official Full Name
transforming growth factor, beta receptor 1 aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-051120-75
See related
Ensembl:ENSDARG00000017494 Vega:OTTDARG00000021555
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
Also known as
tgfbr1; zgc:123263

Genomic context

See tgfbr1a in Genome Data Viewer
Location:
chromosome: 2
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (23855583..23931538, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (24199932..24275887, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene si:dkey-24c2.9 Neighboring gene golgi reassembly stacking protein 1a Neighboring gene collagen, type XV, alpha 1b Neighboring gene solute carrier family 12 (potassium/chloride transporter), member 7a

Genomic regions, transcripts, and products

Pathways from BioSystems

General gene information

Homology

Clone Names

  • MGC123263

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor activity, type I IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transforming growth factor beta-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane receptor protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
activin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pattern specification process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane receptor protein serine/threonine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
activin receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transforming growth factor, beta receptor 1 a
Names
alk5a
transforming growth factor, beta receptor I a
transforming growth factor-beta receptor type I a
NP_001032772.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037683.2NP_001032772.2  transforming growth factor, beta receptor 1 a precursor

    See identical proteins and their annotated locations for NP_001032772.2

    Status: PROVISIONAL

    Source sequence(s)
    EF462417
    UniProtKB/TrEMBL
    B0EXP6
    Related
    ENSDARP00000111880.2, OTTDARP00000022493, ENSDART00000121885.3, OTTDART00000027462
    Conserved Domains (4) summary
    cd14143
    Location:206493
    STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors
    pfam01064
    Location:32103
    Activin_recp; Activin types I and II receptor domain
    pfam07714
    Location:202472
    Pkinase_Tyr; Protein tyrosine kinase
    pfam08515
    Location:173200
    TGF_beta_GS; Transforming growth factor beta type I GS-motif

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    23855583..23931538 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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