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akt3a v-akt murine thymoma viral oncogene homolog 3a [ Danio rerio (zebrafish) ]

Gene ID: 560549, updated on 9-Sep-2025
Official Symbol
akt3aprovided by ZNC
Official Full Name
v-akt murine thymoma viral oncogene homolog 3aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050419-180
See related
Ensembl:ENSDARG00000104810 AllianceGenome:ZFIN:ZDB-GENE-050419-180
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
akt3; si:ch211-221n23.2
Summary
Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within regulation of blood vessel endothelial cell differentiation. Predicted to be active in cytoplasm and nucleus. Is expressed in skeletal muscle. Used to study schizophrenia. Human ortholog(s) of this gene implicated in colon cancer; glioblastoma; prostate adenocarcinoma; prostate cancer; and renal cell carcinoma. Orthologous to human AKT3 (AKT serine/threonine kinase 3). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
human mouse all
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See akt3a in Genome Data Viewer
Location:
chromosome: 13
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 13 NC_133188.1 (11609461..11811111, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 13 NC_007124.7 (11175512..11378305, complement)

Chromosome 13 - NC_133188.1Genomic Context describing neighboring genes Neighboring gene dynein, cytoplasmic 2, light intermediate chain 1 Neighboring gene centrosomal protein 170Aa Neighboring gene SHH signaling and ciliogenesis regulator sdccag8 Neighboring gene uncharacterized LOC141377143 Neighboring gene uncharacterized LOC137487332 Neighboring gene zinc finger and BTB domain containing 18

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Lemairamin (Wgx-50) Attenuates DSS-Induced Intestinal Inflammation in Zebrafish. Zhang L, et al. Int J Mol Sci, 2024 Sep 1. PMID 39273457, Free PMC Article
  2. An Oculus to Profile and Probe Target Engagement In Vivo: How T-REX Was Born and Its Evolution into G-REX. Long MJC, et al. Acc Chem Res, 2021 Feb 2. PMID 33228351
  3. Akt3 is a privileged first responder in isozyme-specific electrophile response. Long MJ, et al. Nat Chem Biol, 2017 Mar. PMID 28114274, Free PMC Article
  4. Akt1 mediates neuronal differentiation in zebrafish via a reciprocal interaction with notch signaling. Cheng YC, et al. PLoS One, 2013. PMID 23342113, Free PMC Article
  5. Size matters: Large copy number losses in Hirschsprung disease patients reveal genes involved in enteric nervous system development. Kuil LE, et al. PLoS Genet, 2021 Aug. PMID 34358225, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of blood vessel endothelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to peptide hormone IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
RAC-gamma serine/threonine-protein kinase
Names
v-akt murine thymoma viral oncogene-like 3
NP_001184130.1
XP_073775722.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001197201.2 → NP_001184130.1  RAC-gamma serine/threonine-protein kinase

    See identical proteins and their annotated locations for NP_001184130.1

    Status: PROVISIONAL

    Source sequence(s)
    HM147246
    UniProtKB/TrEMBL
    A0A8M1NX97, D9IL79
    Related
    ENSDARP00000139879.1, ENSDART00000164566.2
    Conserved Domains (4) summary
    smart00220
    Location:148 → 405
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01241
    Location:4 → 110
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05593
    Location:132 → 479
    STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)
    pfam00169
    Location:6 → 105
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133188.1 Reference GRCz12tu Primary Assembly

    Range
    11609461..11811111 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073919621.1 → XP_073775722.1  RAC-gamma serine/threonine-protein kinase isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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