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Samhd1 SAM domain and HD domain, 1 [ Mus musculus (house mouse) ]

Gene ID: 56045, updated on 9-Jul-2017
Official Symbol
Samhd1provided by MGI
Official Full Name
SAM domain and HD domain, 1provided by MGI
Primary source
MGI:MGI:1927468
See related
Ensembl:ENSMUSG00000027639 Vega:OTTMUSG00000016173
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mg11; E330031J07Rik
Orthologs
Location:
2; 2 H1
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (157097529..157135277, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (156923265..156960958, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2 pseudogene Neighboring gene DSN1 homolog, MIS12 kinetochore complex component Neighboring gene suppressor of glucose, autophagy associated 1 Neighboring gene TBC/LysM associated domain containing 2 Neighboring gene small nuclear ribonucleoprotein Sm D1-like Neighboring gene retinoblastoma-like 1 (p107) Neighboring gene maestro heat-like repeat family member 8 Neighboring gene ribophorin II

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
RNA binding ISO
Inferred from Sequence Orthology
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
dGTP binding ISO
Inferred from Sequence Orthology
more info
 
dGTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
dGTPase activity ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding ISO
Inferred from Sequence Orthology
more info
 
ribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
triphosphoric monoester hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
dATP catabolic process ISO
Inferred from Sequence Orthology
more info
 
dGTP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
dGTP catabolic process ISO
Inferred from Sequence Orthology
more info
 
defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
 
defense response to virus ISO
Inferred from Sequence Orthology
more info
 
immune system process IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
regulation of innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
deoxynucleoside triphosphate triphosphohydrolase SAMHD1
Names
IFN-gamma induced
SAM domain and HD domain-containing protein 1
dNTPase
interferon-gamma-inducible protein Mg11
NP_001132992.1
NP_061339.3
XP_006499984.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001139520.1NP_001132992.1  deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an additional frame-shifting exon in the 3' coding region, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK171565, BC067198, BF148012, BY069979, DV645873
    Consensus CDS
    CCDS50783.1
    UniProtKB/Swiss-Prot
    Q60710
    UniProtKB/TrEMBL
    E9Q0K6
    Related
    ENSMUSP00000124935.1, OTTMUSP00000047129, ENSMUST00000139263.7, OTTMUST00000038707
    Conserved Domains (4) summary
    cd09508
    Location:73142
    SAM_HD; SAM domain of HD-phosphohydrolase
    smart00454
    Location:76142
    SAM; Sterile alpha motif
    COG1078
    Location:147604
    YdhJ; HD superfamily phosphohydrolase [General function prediction only]
    cd00077
    Location:194367
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
  2. NM_018851.3NP_061339.3  deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC067198, BF148012, BY069979, DV645873
    Consensus CDS
    CCDS16973.2
    UniProtKB/Swiss-Prot
    Q60710
    UniProtKB/TrEMBL
    F8WJE0
    Related
    ENSMUSP00000059717.3, OTTMUSP00000017309, ENSMUST00000057725.9, OTTMUST00000038703
    Conserved Domains (4) summary
    cd09508
    Location:73142
    SAM_HD; SAM domain of HD-phosphohydrolase
    smart00454
    Location:76142
    SAM; Sterile alpha motif
    COG1078
    Location:147604
    YdhJ; HD superfamily phosphohydrolase [General function prediction only]
    cd00077
    Location:194367
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

    Range
    157097529..157135277 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499921.2XP_006499984.1  deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1

    Conserved Domains (3) summary
    cd09508
    Location:73142
    SAM_HD; SAM domain of HD-phosphohydrolase
    smart00454
    Location:76142
    SAM; Sterile alpha motif
    smart00471
    Location:192255
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
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