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Rala v-ral simian leukemia viral oncogene A (ras related) [ Mus musculus (house mouse) ]

Gene ID: 56044, updated on 19-Apr-2019

Summary

Official Symbol
Ralaprovided by MGI
Official Full Name
v-ral simian leukemia viral oncogene A (ras related)provided by MGI
Primary source
MGI:MGI:1927243
See related
Ensembl:ENSMUSG00000008859
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ral; Rasl1; AW322615; 3010001O15Rik
Expression
Ubiquitous expression in CNS E18 (RPKM 28.4), CNS E14 (RPKM 21.1) and 28 other tissues See more
Orthologs

Genomic context

See Rala in Genome Data Viewer
Location:
13 A2; 13 6.05 cM
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (17880575..17944217, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (17972409..18036051, complement)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene cyclin-dependent kinase 13 Neighboring gene microRNA 466i Neighboring gene predicted gene, 18859 Neighboring gene ADP-ribosylation factor 3 pseudogene Neighboring gene G patch domain and ankyrin repeats 1 pseudogene Neighboring gene Yae1 domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Pancreatic cancer, organism-specific biosystem (from KEGG)
    Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
  • Pancreatic cancer, conserved biosystem (from KEGG)
    Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Phospholipase D signaling pathway, organism-specific biosystem (from KEGG)
    Phospholipase D signaling pathway, organism-specific biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
  • Phospholipase D signaling pathway, conserved biosystem (from KEGG)
    Phospholipase D signaling pathway, conserved biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
  • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
    Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Rap1 signaling pathway, conserved biosystem (from KEGG)
    Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Ras signaling pathway, organism-specific biosystem (from KEGG)
    Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
  • Translocation of GLUT4 to the plasma membrane, organism-specific biosystem (from REACTOME)
    Translocation of GLUT4 to the plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATPase binding ISO
Inferred from Sequence Orthology
more info
 
Edg-2 lysophosphatidic acid receptor binding ISO
Inferred from Sequence Orthology
more info
 
GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GDP binding ISO
Inferred from Sequence Orthology
more info
 
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTP binding ISO
Inferred from Sequence Orthology
more info
 
GTPase activity EXP
Inferred from Experiment
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
myosin binding ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
exocytosis IEA
Inferred from Electronic Annotation
more info
 
membrane raft localization IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft localization ISO
Inferred from Sequence Orthology
more info
 
neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
 
regulation of exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of exocytosis ISO
Inferred from Sequence Orthology
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface ISO
Inferred from Sequence Orthology
more info
 
cleavage furrow ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
myelin sheath HDA PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ras-related protein Ral-A
Names
RAS-like, family 1
ral-A protein
v-ral simian leukemia viral oncogene homolog A (ras related)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019491.5NP_062364.3  ras-related protein Ral-A precursor

    See identical proteins and their annotated locations for NP_062364.3

    Status: PROVISIONAL

    Source sequence(s)
    CT009754
    Consensus CDS
    CCDS26255.1
    UniProtKB/Swiss-Prot
    P63321
    Related
    ENSMUSP00000009003.7, ENSMUST00000009003.8
    Conserved Domains (1) summary
    cd04139
    Location:15177
    RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

    Range
    17880575..17944217 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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