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Rala v-ral simian leukemia viral oncogene A (ras related) [ Mus musculus (house mouse) ]

Gene ID: 56044, updated on 27-May-2024

Summary

Official Symbol
Ralaprovided by MGI
Official Full Name
v-ral simian leukemia viral oncogene A (ras related)provided by MGI
Primary source
MGI:MGI:1927243
See related
Ensembl:ENSMUSG00000008859 AllianceGenome:MGI:1927243
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ral; Rasl1; 3010001O15Rik
Summary
Enables GTPase activity. Involved in membrane raft localization; neural tube closure; and regulation of exocytosis. Located in myelin sheath. Is expressed in several structures, including alimentary system; central nervous system; eye; heart; and skin. Orthologous to human RALA (RAS like proto-oncogene A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 28.4), CNS E14 (RPKM 21.1) and 28 other tissues See more
Orthologs
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Genomic context

See Rala in Genome Data Viewer
Location:
13 A2; 13 6.05 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (18055160..18118802, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (17880575..17944217, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24018 Neighboring gene predicted gene, 18859 Neighboring gene STARR-seq mESC enhancer starr_33765 Neighboring gene ADP-ribosylation factor 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_33767 Neighboring gene G patch domain and ankyrin repeats 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7206 Neighboring gene Yae1 domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
 
enables Edg-2 lysophosphatidic acid receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables G protein activity IEA
Inferred from Electronic Annotation
more info
 
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GDP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity EXP
Inferred from Experiment
more info
PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables myosin binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in establishment of protein localization to mitochondrion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within exocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in membrane raft localization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in membrane raft localization ISO
Inferred from Sequence Orthology
more info
 
involved_in neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitochondrial fission ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynaptic neurotransmitter receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cleavage furrow ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle membrane TAS
Traceable Author Statement
more info
 
colocalizes_with endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in synaptic membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ras-related protein Ral-A
Names
RAS-like, family 1
ral-A protein
v-ral simian leukemia viral oncogene homolog A (ras related)
NP_062364.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019491.5NP_062364.3  ras-related protein Ral-A

    See identical proteins and their annotated locations for NP_062364.3

    Status: PROVISIONAL

    Source sequence(s)
    CT009754
    Consensus CDS
    CCDS26255.1
    UniProtKB/Swiss-Prot
    P63321
    UniProtKB/TrEMBL
    Q9CXY0
    Related
    ENSMUSP00000009003.8, ENSMUST00000009003.9
    Conserved Domains (1) summary
    cd04139
    Location:15177
    RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    18055160..18118802 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)