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Uso1 USO1 vesicle docking factor [ Mus musculus (house mouse) ]

Gene ID: 56041, updated on 12-May-2024

Summary

Official Symbol
Uso1provided by MGI
Official Full Name
USO1 vesicle docking factorprovided by MGI
Primary source
MGI:MGI:1929095
See related
Ensembl:ENSMUSG00000029407 AllianceGenome:MGI:1929095
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TAP; Vdp; 115kDa
Summary
Acts upstream of or within several processes, including regulation of cellular response to insulin stimulus; secretory granule localization; and small GTPase mediated signal transduction. Located in cytosol and perinuclear region of cytoplasm. Is expressed in central nervous system and retina. Orthologous to human USO1 (USO1 vesicle transport factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 26.6), genital fat pad adult (RPKM 19.3) and 28 other tissues See more
Orthologs
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Genomic context

See Uso1 in Genome Data Viewer
Location:
5 E2; 5 46.05 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (92285770..92350659)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (92137909..92202800)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene G3BP stress granule assembly factor 2 Neighboring gene STARR-positive B cell enhancer mm9_chr5:92512687-92512988 Neighboring gene predicted gene, 46933 Neighboring gene STARR-seq mESC enhancer starr_13632 Neighboring gene uncharacterized LOC105246914 Neighboring gene STARR-seq mESC enhancer starr_13633 Neighboring gene STARR-positive B cell enhancer ABC_E11293 Neighboring gene ribosomal protein L13 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:92612573-92612756 Neighboring gene predicted gene, 25290 Neighboring gene predicted gene, 42113 Neighboring gene cDNA sequence U90926 Neighboring gene predicted gene, 42112

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Golgi organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in Golgi vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in membrane fusion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in membrane fusion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within secretory granule localization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within small GTPase-mediated signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transcytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in transcytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle fusion with Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in ER to Golgi transport vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in Golgi stack IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
general vesicular transport factor p115
Names
USO1 homolog, vesicle docking protein
protein USO1 homolog
transcytosis associated protein p115
transcytosis-associated protein
vesicle docking protein, 115 kDa
vesicle-docking protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417623.1NP_001404552.1  general vesicular transport factor p115 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122438, AC125542
  2. NM_001417624.1NP_001404553.1  general vesicular transport factor p115 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122438, AC125542
  3. NM_001417625.1NP_001404554.1  general vesicular transport factor p115 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC122438, AC125542
  4. NM_001417626.1NP_001404555.1  general vesicular transport factor p115 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC122438, AC125542
  5. NM_001417627.1NP_001404556.1  general vesicular transport factor p115 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC122438, AC125542
    Related
    ENSMUSP00000144592.2, ENSMUST00000202155.2
  6. NM_001417628.1NP_001404557.1  general vesicular transport factor p115 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC122438, AC125542
  7. NM_019490.2NP_062363.1  general vesicular transport factor p115 isoform 2

    See identical proteins and their annotated locations for NP_062363.1

    Status: VALIDATED

    Source sequence(s)
    AC122438, AC125542
    Consensus CDS
    CCDS39150.1
    UniProtKB/Swiss-Prot
    Q3T9L9, Q3TH58, Q3U1C7, Q3UMW6, Q91WE7, Q99JZ5, Q9Z1Z0
    Related
    ENSMUSP00000031355.7, ENSMUST00000031355.10
    Conserved Domains (3) summary
    cd00020
    Location:19153
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam04869
    Location:347628
    Uso1_p115_head; Uso1 / p115 like vesicle tethering protein, head region
    pfam04871
    Location:841934
    Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    92285770..92350659
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535141.5XP_006535204.1  general vesicular transport factor p115 isoform X2

    Conserved Domains (3) summary
    COG1196
    Location:652906
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam04869
    Location:347635
    Uso1_p115_head; Uso1 / p115 like vesicle tethering protein, head region
    pfam18770
    Location:269329
    Arm_vescicular; Armadillo tether-repeat of vescicular transport factor
  2. XM_036165322.1XP_036021215.1  general vesicular transport factor p115 isoform X4

    Conserved Domains (3) summary
    COG1196
    Location:487774
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam04869
    Location:182470
    Uso1_p115_head; Uso1 / p115 like vesicle tethering protein, head region
    pfam18770
    Location:105164
    Arm_vescicular; Armadillo tether-repeat of vescicular transport factor